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Testimony06 icon15年前有两位银屑病(牛皮癣)女生同时来看唐老医生,一位选择了西药治疗,一位选择留下来凭信心接受传统中草药治疗。15年后,这位接受唐老先生治疗的女孩见到那位在医院接受治疗的朋友,惊讶的发现两人的皮肤状况居然有如此天壤之别,她怀着无比激动的心情回来向唐老先生致谢。

 

case16 iconA 20-year-old previously healthy man presented with progressive rash, low-grade fever and arthralgia that involved the knees and ankles that had lasted for 2 months despite treatment with oral prednisolone and naproxen, arthralgia is under control, but rashes developed more.

 

 

Alert 19 icon

Steroids have adverse effects: growth retardation in children, immunosuppression, hypertension, inhibition of wound repair, osteoporosis, and metabolic disturbances. All these harmful properties contraindicate prolonged glucocorticoid therapy.

 

 

Alert 18 icon

Immunosuppressive drugs are applied to control autoimmune disorders and inflammation when excessive tissue damage occurs, as well as to prevent transplant rejection after an organ transplant. Increasing evidence shows that cordyceps is a bidirectional modulator with both potentiating and suppressive effects on the immune system through regulating innate and adaptive immunity. 

 

 

Reference:

Feng K, Yang Y. Q, Li S. P. Renggongchongcao. In: Li S. P, Wang Y. T, editors. Pharmacological Activity-Based Quality Control of Chinese Herbs. New York: Nova Science Publisher, Inc.; 2008. pp. 155–78.

Li S. P, Tsim K. W. The biological and pharmacological properties of Cordyceps sinensis, a traditional Chinese medicine that has broad clinical applications. In: Herbal and Traditional Medicine. New York: Marcel Dekker; 2004. pp. 657–82.

Ng T. B, Wang H. X. Pharmacological actions of Cordyceps, a prized folk medicine. J Pharm Pharmacol. 2005;57:1509–19.

Zhou X, Gong Z, Su Y, Lin J, Tang K. Cordyceps fungi: Natural products, pharmacological functions and developmental products. J Pharm Pharmacol. 2009a;61:279–91.

Alert 16 iconRosacea, perioral dermatitis, acne; Skin atrophy with telangiectasia, stellate pseudo scars(arms), purpura, striae (from anatomic occlusion, e.g., groin); Tinea incognito, impetigo incognito, scabies incognito; Ocular hypertension, glaucoma, cataracts; Allergic contact dermatitis; Systemic absorption; Burning, itching, irritation, dryness caused by vehicle(e.g., propylene glycol); Miliaria and folliculitus following occlusion with plastic dressing; Skin blanching from acute vasoconstriction; Rebound phenomenon (e.g., psoriasis becomes worse after treatment is stopped); Nonhealing leg ulcers; steroids applied to any leg ulcerated healing process; Hypopigmentation; Hypertrichosis of face.

 

Reference:

Thomas P. Habif: Clinical Dermatology,A Color Guide to Diagnosis and Therapy, 6th Edition.
2016. Elsevier. Page82-89

Alert 16 iconSteroids withdrawal (addiction) syndrome is a distinct clinical adverse effect of steroid misuse (Hagar T, Leshem YA, Hannifin JM, etc. 2015). Patients and physicians should be aware of its clinical features and risk factors to identify and prevent this complication. 76.7% of patients with steroid withdrawal syndrome received complete or partial clearance in 3 months, 12.5% in 6 months, 5.5% in 12 months and 5.1% over 12 months respectively after discontinuation use of steroid.

 

 

 

Reference:

Hagar T, Leshem YA, Hannifin JM, etc. (2015) Asystematic review of topical corticosteroid withdraw (steroid addiction) in patients with atopic dermatitis and other dermatoses. J Am Acad Dermatol 2015;72:541-549

Alert_15_iconThe prevalence of psoriasis in the US was estimated to be 7.4 million in 2013. Comparatively,psoriasis patients incurred incremental medical costs of $2284, experienced a $2203 reduction in HRQOL, and a $1935 reduction in productivity. The total burden of psoriasis was estimated as $35.2 billion, with $12.2 billion in incremental medical costs (35%), $11.8 billion from reduced HRQOL (34%), and $11.2 billion from productivity losses (32%).

 

 

 

Reference:

Jacqueline Vanderpuye-Orgle, Yang Zhao, Jackie Lu, etc. (2015) Evaluating the economic burden of psoriasis in the United States. J Am Acad Dermatol 2015;71:961-967

This article first appeared in MyPaper on 31 July 2014

http://mypaper.sg/chinese-specials/zhi-liao-shi-zhen-quan-yong-yao-wei-shou-yao-20140731

治疗湿疹 安全用药为首要

湿 疹(Eczema)又名异位性皮炎(Atopic Dermatitis)或遗传过敏性湿疹。异位性(Atopy)的含义是患者或家族成员有罹患哮喘病、枯草热、过敏性鼻炎、荨麻疹、湿疹等病史、对异种蛋 白过敏、病人血清中免疫球蛋白E值增高、患者血清中嗜酸性白细胞增多。

遗传性过敏是病因之一,患者本人及其家族中成员对某些外在物质的敏 感性往往高于正常人。据统计显示,双亲皆有“异位性”症候群,约70%后代也遗传“异位性”。若父母中仅一方见“异位性”,则子女大致半数遗传“异位 性”。然而在“异位性”病人中,还有40%的父母未发现“异位性”征候。

Alert_14_iconFrom 1956 to July 2013, there were 32 observational studies (512420 participants) of fatty acids from dietary intake; 17 observational studies (25721 participants) of fatty acid biomarkers; and 27 randomized, controlled trials (105085 participants) of fatty acid supplementation. Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids and low consumption of total saturated fats.

 

 

 

Reference:

Rajiv Chowdhury, Samantha Warnakula, Setor Kunutsor et al. (2014) Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis. Ann Intern Med. 2014;160:398-406.

According to a recent research which was published and recognized in the British Medical Journal’s respiratory journal Thorax, youngsters and teenagers who are fond of fast food consumption are more likely to develop asthma, eczema and hay fever


An international research team has published data from a group of studies, which have uncovered new genetic variants associated with the autoimmune disease, psoriasis.

Tagged in: Psoriasis

Researchers at Oregon State University have made new discoveries about the genetic substrate of atopic dermatitis. It was found that inadequate Ctip2, a protein that has genetic functions, may trigger the disease through several mechanisms. These findings may provide new therapeutic targets for treating dermatitis.

Atopic dermatitis or Eczema is a skin condition that frequently occurs in young children, although it may start in young adults and can continue into adult life.

Itching of the skin can be caused by irritants, infections, allergies and stress.

Avoiding allergens such as animal dander, dust mites and cockroaches can improve atopic dermatitis. Eliminating foods to which a person is allergic will also result in the improvement of the eczema.

Dating is rarely easy for anyone. But when you live with a disfiguring skin disease like psoriasis, you have another layer of anxiety to add to the everyday stresses of finding a partner.

Tagged in: Psoriasis

People with the skin disorder psoriasis might be at higher risk for heart failure and should be screened for heart disease, experts say.

Tagged in: Psoriasis

Teenagers and young children who eat fast food could be increasing their risk of developing asthma, eczema and hay fever, according to a study published Monday in the British Medical Journal's respiratory journal Thorax.

The International Study of Asthma and Allergies in Childhood (ISAAC) study used written questionnaires completed by 319,196 13-  and 14-year-olds from 51 countries and by the parents of 181,631 6- and 7-year-olds in 31 countries.  They were asked if they had symptoms of the three conditions and about their weekly diet - including the types of foods they ate over the last year, and how often.

Need to know everything about Eczema in Australia and Asia? Check out Eczema Assoication of Austrasia website.

Psoriasis is an immune-mediated skin disease that causes the excessive growth of skin cells, and usually brings the red and scaly patches along with it. There are five types of psoriasis, each with different types of symptoms.

Tagged in: Psoriasis

The National Psoriasis Foundation has a wealth of great resources and tools to help you manage your disease and live well with psoriasis or psoriatic arthritis.

Tagged in: Psoriasis

Psoriasis is a recurrent and complex inflammatory skin disorder that can have tremendous physical and psychological impact on the sufferer.
Psoriasis is a complex, inflammatory disease which mostly affects the skin and joints. It is however not a contagious disease.

Tagged in: Psoriasis

alert_12_iconThe health benefits of organic foods are unclear. To review evidence comparing the health effects of organic and conventional foods. MEDLINE (January 1966 to May 2011), EMBASE, CAB Direct, Agricola, TOXNET, Cochrane Library (January 1966 to May 2009), and bibliographies of retrieved articles. English-language reports of comparisons of organically and conventionally grown food or of populations consuming these foods. 17 studies in humans and 223 studies of nutrient and contaminant levels in foods met inclusion criteria.

 


Reference:
Crystal Smith-Spangler, Margaret L. Brandeau, Grace E. Hunter,  et al.  (2012). Are Organic Foods Safer or Healthier Than Conventional Alternatives? A Systematic Review.  Annals of Internal Medicine. 2012;157:348-366.

Alert_11_iconThe omega-6 fatty acids are the predominant polyunsaturated fats. The omega-6 and omega-3 fatty acids are metabolically distinct and have opposing physiologic functions. Animal and human studies support the hypothesis that omega-3 PUFA suppress cell mediated immune responses. The increased omega-6/omega-3 ratio in Western diets most likely contributes to an increased incidence of cardiovascular disease and inflammatory disorders.


 

Reference:
Virella G, Fourspring K, Hyman B, Haskill-Stroud R, Long L, Virella I, La Via M, Gross AJ, Lopes-Virella M. (1991). Immunosuppressive effects of fish oil in normal human volunteers: correlation with the in vitro effects of eicosapentanoic acid on human lymphocytes. Clinical Immunology and Immunopathology. 1991 Nov;61(2 Pt 1):161-76.

Park HJ, Park JS, Hayek MG, Reinhart GA, Chew BP. (2011). Dietary fish oil and flaxseed oil suppress inflammation and immunity in cats. Veterinary Immunology and Immunopathology. 2011 Jun 15;141(3-4):301-6. doi: 10.1016/j.vetimm.2011.02.024. Epub 2011 Mar 6.

Simopoulos AP. (2002). Omega-3 fatty acids in inflammation and autoimmune diseases. Journal of the American College of Nutrition. 2002 Dec;21(6):495-505.

Alert10_iconPearce and colleagues110 examined the cost-effectiveness of psoriasis treatments over a 12-week period comparing methotrexate, acitretin, cyclosporine, narrow band UV-B, PUVA, etanercept, and efalizumab. The total cost per completed treatment regimen was calculated based on drug acquisition costs, dosing and cost of physician visits, laboratory testing, phototherapy treatment charges, liver biopsy, and infusions charges.

 

 

Reference:
Li Kai & Armstrong April W. (2012). A Review of Health Outcomes in Patients with Psoriasis. Dermatologic Clinics. Volume 30, Issue 1, Pages 61-72, January 2012
Tagged in: Psoriasis

I happen to come across an article on Psoriasis on National Skin Centre website. I find it short and concise,making it easy to understand.It is coupled with some illustrative photos.

 

Tagged in: Psoriasis

These days, there's so much information available in so many different formats, it can be a little overwhelming. So, to make things easier, here's a list of some government health sites, directories of dermatologists, and medical journals, as well as other people's psoriasis stories that you may find helpful.

 

Tagged in: Psoriasis

You will need to work out your treatment plan with your doctor. Understand what treatment options are available, how long you will need to wait to see results, and when to move on to another option if the desired outcome is not achieved. Over time, as your general health and the severity of your psoriasis changes, you may need to review your options.

Tagged in: Psoriasis

The Psoriasis Newsletter is published every 4 months and is distributed to all registered PAS members.

 

Tagged in: Psoriasis

I happen to come across this website which have a lot of articles relating Psoriasis problems affecting African Americans (Blacks).

 

A selection of useful eczema / psoriasis website links and resources.

 

Keep abreast of more news about Psoriasis at Health Magazine. Over there,it contains a lot of information that would be informative and beneficial to psoriasis sufferers.

 

Tagged in: Psoriasis

Dr. Alan Menter has found his passion in a disease that is red and itchy, a disease that gets sufferers kicked out of public swimming pools, a disease that controls wardrobe and intimacy and can lead to a host of other health problems.

 

Tagged in: Psoriasis

Q: I have been trying to find out the difference between atopic dermatitis and contact dermatitis. I have noticed a rash, severe at times while wearing certain clothing. It is usually around my feet and ankles. The rash goes away after removing the clothing and boots and never occurs in my normal clothing. Any information you may have will be beneficial.

 

The National Psoriasis Foundation has a wealth of great resources and tools to help you manage your disease and live well with psoriasis or psoriatic arthritis.

 

Tagged in: Psoriasis
  • Psoriasis is a serious medical condition affecting the autoimmune system.
  • The most common form, which affects about 80 percent of people who have the condition, is plaque psoriasis. It is characterized by patches of raised, reddish skin covered with silvery-white scales. Psoriasis usually occurs on the scalp, knees, elbows, hands and feet.
  • About 7.5 million Americans have psoriasis.
  • In 2004, the total direct cost of treatment associated with psoriasis was $1.2 billion.

 

Tagged in: Psoriasis

The reality star has always been open about her psoriasis, but her skin has been looking worse as her pregnancy moves on. Dermatologists reveal to HollywoodLife.com EXCLUSIVELY why her skin condition is flaring up.

 

Tagged in: Psoriasis

Alert9_icon

A 73-year-old man who had had plaque psoriasis for more than 20 years on the arms, legs, and scalp presented for consultation on a new rash. He had been using topical steroid creams and shampoos to control occasional psoriatic flares.

 

 

 

Reference:
Jashin J. Wu, Caroline Caperton. (2013). Psoriasis Flare from Koebner’s Phenomenon after Acupuncture. New England Journal of Medicine. 2013; 368:1635April 25, 2013DOI: 10.1056/NEJMicm120571

Tagged in: Psoriasis

Alert_8_icon

A total of 1095 patients with moderate to severe plaque psoriasis from 10 dermatology practices was studied,patients stopped systemic treatments (MTX, Acitretin, Cyclosporine) and phototherapy (UVB and PUVA) after medians of 6 to 12 months and biologic agents (Etanercept, Adalimumab, Infliximab) after medians of 12 to 20.5 months. Side effects and lost efficacy are important limiting factors for treatment persistence.

 

 

Reference:
Howa Yeung, Joy Wan, Abby S. Van Voorhees, Kristina Callis Duffin, Gerald G. Krueger,Robert E. Kalb, Jamie D. Weisman, Brian R. Sperber, Bruce A. Brod, Stephen M. Schleicher, Bruce F. Bebo, Jr, Daniel B. Shin, Andrea B. Troxel, Joel M. Gelfand. (2013). Patient-reported reasons for the discontinuation of commonly used treatments for moderate to severe psoriasis. Journal of the American Academy of Dermatology. 2013;68:64-72.

Tagged in: Psoriasis

 

A 10-year-old female presents in this clinic with crusted itchy skin with 5 years of eczematous duration

Corticosteroids are commonly prescribed by practitioners in many medical specialties for the treatment of chronic inflammatory conditions. The use of corticosteroids in the treatment of chronic rhinosinusitis is well described and based on their anti-inflammatory effects. The duration of corticosteroid therapy in these conditions is often less than 1 month, in contrast to the treatment of chronic respiratory diseases (ie, asthma, chronic obstructive pulmonary disease) or autoimmune disorders (ie, rheumatoid arthritis, systemic lupus erythematosus, Crohn disease, and ulcerative colitis), which can last for years.

 

Reference:
David M. Poetker, Douglas D. Reh. (2010). A Comprehensive Review of the Adverse Effects of Systemic Corticosteroids.  Otolaryngologic Clinics of North America. 43 (2010) 753–768 doi:10.1016/j.otc.2010.04.003

This paper is to search for an effective immunosuppressant from Glycyrrhiza uralensis (Licorice, Gan Cao). Our results show the immunosuppressive activity of glycyrol and this activity should be due to its inhibitory effect on CN activity, thereby suppressing IL-2 production and regulating T lymphocytes. Thus, glycyrol could be a candidate for development as a novel immunomodulatory drug.

 

 

Reference:
Jiayu Li1, Ying Tu1, Li Tong, Wen Zhang, Jianquan Zheng, and Qun Wei. (2010). Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity. Pharmaceutical Biology, 2010; 48(10): 1177–1184

Biologic compounds are being used more frequently to treat a multitude of systemic inflammatory conditions. These novel compounds are composed of antibodies or other peptides that act through one of three mechanisms: inhibiting inflammatory cytokine signaling (typically tumor necrosis factor or TNF), inhibiting T-cell activation, or depleting B-cells. The increase in use and ever expanding list of new immune modulating therapies make knowledge of the infectious complications associated with immune modulation even more important. Of particular concern is the risk for developing atypical and opportunistic infections including tuberculosis, herpes zoster, Legionella pneumophila, and Listeria monocytogenes.

Reference:
Rachel Gordon, Rana Mays, Hung Doan, Whitney Lapolla, Stephen K. Tyring. (2012). Biologic Therapy and Risk of Infection. Skin therapy Letter. Volume 17, Number 4, Aprial 2012.

Testimony 5

t5_iconMichelle suffered with 8 years of weeping eczema, repeated application to the entire palm and legs sesulted in her diffuse waterish eruption, the inflammation improved each time the topical steroid was used but flared with incresing intensity each time the medication was stopped.

Testimony 4

t4_iconA35-year-old mael Singaporean presented in May 2004 at our clinic with symptoms and signs of rash and erythema papules accompany with severe itchy all over his face and body. He was diagnosed with eczema 8 years ago, itchiess and reashes initally subsided following several courses of a group III topical steroid to affected skin area, but inflammation flares shortly after the topical steroid is discountinued..

Testimony 3

t3_iconMy daughter Mun had had eczema since she was an infant. Until the age of 12, her condition could be controlled quite easily with creams and antihistamines.

 

Testimony 2

t2_Nicholas_20040415This is my personal testimony.I am 42-year-old Indian, was a victim of psoriasis and had suffered from the chronic disease since 1994.

 

Testimony 1

t1_Anthony2My name is Clarence and I had been suffering from guttate psoriasis since 2001 after bad bouts of sore throat and asthma.

 

 

Alert4_iconIn this Volume 65, Issue 1 of the JAAD, Kerner et al report blunted adrenal responses after the use of topical corticosteroids. While it is reassuring that laboratory values remained within the normal range in this particular study, the blunted responses serve as a reminder that systemic absorption of topically applied corticosteroids can have systemic implications.

 

 

 

Reference:
Lynnette K. Nieman. (2011) Consequences of systemic absorption of topical glucocorticoids. Journal of the American Academy of Dermatology. Volume 65, Issue 1 , Pages 250-252

The role of resveratrol (can be extracted from grape, veratrum album which commonly known as the False Helleborine, also known as White Hellebore, European White Hellebore, White Veratrum) and curcumin (extracted from Turmeric, also known as yellow ginger) is well documented in cancer, inflammation, diabetes and various other diseases. However, their immuinnosuppressive action on T cells, B cells and macrophages is not well documented.

 

 

Reference:
Sharma S,Chopra K,Kulkarniand Sk, Agrewala JN. (2006). Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway. Clinical and Experimental Immunology. 2006. 147:155-163.

alert2_iconThe use of anabolic supplements and other related drugs for bodybuilding and enhancing athletic performance is nowadays widespread and acutely pervasive all around the world. This alarming increase in the use of anabolic and amino acid supplements has been linked to a diverse array of pathologies. As previously reported, the abuse of androgenic steroids is not without severe physiological, psychiatric and physical costs.

Reference:
Ali A Samaha1, Walid Nasser-Eddine1, Elizabeth Shatila, John J Haddad, Jaafar Wazne and Ali H Eid. (2008). Multi-organ damage induced by anabolic steroid supplements: a case report and literature review. Journal of Medical Case Reports 2008, 2:340 doi:10.1186/1752-1947-2-340

alert1_iconThese cases demonstrate that atopic dermatitis and topical corticosteroids may be associated with cataracts in children as well as adults. The cause of cataracts in atopic dermatitis is not known. However, it has been suggested that habitual tapping and rubbing of the face may play a role. Care needs to be taken when prescribing corticosteroids. Inadequate treatment of atopic dermatitis may lead to other ocular complications such as keratitis and permanent visual loss.

Reference:
Andrew Tatham. (2008). Atopic dermatitis, cutaneous steroids and cataracts in children: two case reports. Journal of Medical Case Reports. 2008. 2:124. doi:10.1186/1752-1947-2-124