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19
Jan
0

Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs

Posted by on in Skin Matters

Alert 19 icon

Steroids have adverse effects: growth retardation in children, immunosuppression, hypertension, inhibition of wound repair, osteoporosis, and metabolic disturbances. All these harmful properties contraindicate prolonged glucocorticoid therapy.

 

 

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30
Oct
0

Cordyceps an immunosuppressive drug

Posted by on in Skin Matters

Alert 18 icon

Immunosuppressive drugs are applied to control autoimmune disorders and inflammation when excessive tissue damage occurs, as well as to prevent transplant rejection after an organ transplant. Increasing evidence shows that cordyceps is a bidirectional modulator with both potentiating and suppressive effects on the immune system through regulating innate and adaptive immunity. 

 

 

Reference:

Feng K, Yang Y. Q, Li S. P. Renggongchongcao. In: Li S. P, Wang Y. T, editors. Pharmacological Activity-Based Quality Control of Chinese Herbs. New York: Nova Science Publisher, Inc.; 2008. pp. 155–78.

Li S. P, Tsim K. W. The biological and pharmacological properties of Cordyceps sinensis, a traditional Chinese medicine that has broad clinical applications. In: Herbal and Traditional Medicine. New York: Marcel Dekker; 2004. pp. 657–82.

Ng T. B, Wang H. X. Pharmacological actions of Cordyceps, a prized folk medicine. J Pharm Pharmacol. 2005;57:1509–19.

Zhou X, Gong Z, Su Y, Lin J, Tang K. Cordyceps fungi: Natural products, pharmacological functions and developmental products. J Pharm Pharmacol. 2009a;61:279–91.

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31
Jul
0

Adverse Reactions to Topical Steroids

Posted by on in Skin Matters

Alert 16 iconRosacea, perioral dermatitis, acne; Skin atrophy with telangiectasia, stellate pseudo scars(arms), purpura, striae (from anatomic occlusion, e.g., groin); Tinea incognito, impetigo incognito, scabies incognito; Ocular hypertension, glaucoma, cataracts; Allergic contact dermatitis; Systemic absorption; Burning, itching, irritation, dryness caused by vehicle(e.g., propylene glycol); Miliaria and folliculitus following occlusion with plastic dressing; Skin blanching from acute vasoconstriction; Rebound phenomenon (e.g., psoriasis becomes worse after treatment is stopped); Nonhealing leg ulcers; steroids applied to any leg ulcerated healing process; Hypopigmentation; Hypertrichosis of face.

 

Reference:

Thomas P. Habif: Clinical Dermatology,A Color Guide to Diagnosis and Therapy, 6th Edition.
2016. Elsevier. Page82-89

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31
May
0

A systematic review of topical corticosteroid withdrawal (steroid addiction) in patients with atopic dermatitis and other dermatoses

Posted by on in Skin Matters

Alert 16 iconSteroids withdrawal (addiction) syndrome is a distinct clinical adverse effect of steroid misuse (Hagar T, Leshem YA, Hannifin JM, etc. 2015). Patients and physicians should be aware of its clinical features and risk factors to identify and prevent this complication. 76.7% of patients with steroid withdrawal syndrome received complete or partial clearance in 3 months, 12.5% in 6 months, 5.5% in 12 months and 5.1% over 12 months respectively after discontinuation use of steroid.

 

 

 

Reference:

Hagar T, Leshem YA, Hannifin JM, etc. (2015) Asystematic review of topical corticosteroid withdraw (steroid addiction) in patients with atopic dermatitis and other dermatoses. J Am Acad Dermatol 2015;72:541-549

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29
May
0

Evaluating the economic burden of psoriasis in the United States

Posted by on in Skin Matters

Alert_15_iconThe prevalence of psoriasis in the US was estimated to be 7.4 million in 2013. Comparatively,psoriasis patients incurred incremental medical costs of $2284, experienced a $2203 reduction in HRQOL, and a $1935 reduction in productivity. The total burden of psoriasis was estimated as $35.2 billion, with $12.2 billion in incremental medical costs (35%), $11.8 billion from reduced HRQOL (34%), and $11.2 billion from productivity losses (32%).

 

 

 

Reference:

Jacqueline Vanderpuye-Orgle, Yang Zhao, Jackie Lu, etc. (2015) Evaluating the economic burden of psoriasis in the United States. J Am Acad Dermatol 2015;71:961-967

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04
Aug
0

MyPaper Writeup on HerosePharma in Chinese

Posted by on in Interesting Reads

This article first appeared in MyPaper on 31 July 2014

http://mypaper.sg/chinese-specials/zhi-liao-shi-zhen-quan-yong-yao-wei-shou-yao-20140731

治疗湿疹 安全用药为首要

湿 疹(Eczema)又名异位性皮炎(Atopic Dermatitis)或遗传过敏性湿疹。异位性(Atopy)的含义是患者或家族成员有罹患哮喘病、枯草热、过敏性鼻炎、荨麻疹、湿疹等病史、对异种蛋 白过敏、病人血清中免疫球蛋白E值增高、患者血清中嗜酸性白细胞增多。

遗传性过敏是病因之一,患者本人及其家族中成员对某些外在物质的敏 感性往往高于正常人。据统计显示,双亲皆有“异位性”症候群,约70%后代也遗传“异位性”。若父母中仅一方见“异位性”,则子女大致半数遗传“异位 性”。然而在“异位性”病人中,还有40%的父母未发现“异位性”征候。 Continue reading
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03
Apr
0

Does high consumption of polyunsaturated fatty (Omega-3, Omega-6, Alpha-linolenic) acids and low consumption of total saturated fats benefit coronary disease?

Posted by on in Skin Matters

Alert_14_iconFrom 1956 to July 2013, there were 32 observational studies (512420 participants) of fatty acids from dietary intake; 17 observational studies (25721 participants) of fatty acid biomarkers; and 27 randomized, controlled trials (105085 participants) of fatty acid supplementation. Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids and low consumption of total saturated fats.

 

 

 

Reference:

Rajiv Chowdhury, Samantha Warnakula, Setor Kunutsor et al. (2014) Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis. Ann Intern Med. 2014;160:398-406.

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17
Jan
0

Fast food might cause allergic conditions such as Asthma, Hay Fever and Eczema, Research

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According to a recent research which was published and recognized in the British Medical Journal’s respiratory journal Thorax, youngsters and teenagers who are fond of fast food consumption are more likely to develop asthma, eczema and hay fever


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16
Nov
0

Study finds new genetic links to psoriasis

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An international research team has published data from a group of studies, which have uncovered new genetic variants associated with the autoimmune disease, psoriasis.

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Tagged in: Psoriasis
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13
Nov
0

Genetic basis for atopic dermatitis found

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Researchers at Oregon State University have made new discoveries about the genetic substrate of atopic dermatitis. It was found that inadequate Ctip2, a protein that has genetic functions, may trigger the disease through several mechanisms. These findings may provide new therapeutic targets for treating dermatitis.

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