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10
May
0

Atopic Dermatitis vs. Contact Dermatitis

Posted by on in Interesting Reads

Q: I have been trying to find out the difference between atopic dermatitis and contact dermatitis. I have noticed a rash, severe at times while wearing certain clothing. It is usually around my feet and ankles. The rash goes away after removing the clothing and boots and never occurs in my normal clothing. Any information you may have will be beneficial.

 

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10
May
0

National Psoriasis Foundation: Resources & Tools

Posted by on in Interesting Reads

The National Psoriasis Foundation has a wealth of great resources and tools to help you manage your disease and live well with psoriasis or psoriatic arthritis.

 

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Tagged in: Psoriasis
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10
May
0

AAD Brief Writeup on Psoriasis

Posted by on in Interesting Reads
  • Psoriasis is a serious medical condition affecting the autoimmune system.
  • The most common form, which affects about 80 percent of people who have the condition, is plaque psoriasis. It is characterized by patches of raised, reddish skin covered with silvery-white scales. Psoriasis usually occurs on the scalp, knees, elbows, hands and feet.
  • About 7.5 million Americans have psoriasis.
  • In 2004, the total direct cost of treatment associated with psoriasis was $1.2 billion.

 

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Tagged in: Psoriasis
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10
May
0

Kim Kardashian’s Pregnancy Stress Making Her Psoriasis Worse – Experts

Posted by on in Interesting Reads

The reality star has always been open about her psoriasis, but her skin has been looking worse as her pregnancy moves on. Dermatologists reveal to HollywoodLife.com EXCLUSIVELY why her skin condition is flaring up.

 

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Tagged in: Psoriasis
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29
Apr
0

Psoriasis Flare from Koebner’s Phenomenon after Acupuncture

Posted by on in Skin Matters

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A 73-year-old man who had had plaque psoriasis for more than 20 years on the arms, legs, and scalp presented for consultation on a new rash. He had been using topical steroid creams and shampoos to control occasional psoriatic flares.

 

 

 

Reference:
Jashin J. Wu, Caroline Caperton. (2013). Psoriasis Flare from Koebner’s Phenomenon after Acupuncture. New England Journal of Medicine. 2013; 368:1635April 25, 2013DOI: 10.1056/NEJMicm120571

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Tagged in: Psoriasis
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26
Dec
0

Patient-reported reasons for the discontinuation of commonly used treatments for moderate to severe psoriasis

Posted by on in Skin Matters

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A total of 1095 patients with moderate to severe plaque psoriasis from 10 dermatology practices was studied,patients stopped systemic treatments (MTX, Acitretin, Cyclosporine) and phototherapy (UVB and PUVA) after medians of 6 to 12 months and biologic agents (Etanercept, Adalimumab, Infliximab) after medians of 12 to 20.5 months. Side effects and lost efficacy are important limiting factors for treatment persistence.

 

 

Reference:
Howa Yeung, Joy Wan, Abby S. Van Voorhees, Kristina Callis Duffin, Gerald G. Krueger,Robert E. Kalb, Jamie D. Weisman, Brian R. Sperber, Bruce A. Brod, Stephen M. Schleicher, Bruce F. Bebo, Jr, Daniel B. Shin, Andrea B. Troxel, Joel M. Gelfand. (2013). Patient-reported reasons for the discontinuation of commonly used treatments for moderate to severe psoriasis. Journal of the American Academy of Dermatology. 2013;68:64-72.

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07
Oct
0

A 10-year-old girl with 5 years of eczema flared up with oozing and crust involved 30% of body surface area

Posted by on in Original Cases

Case 15 Presentation

A 10-year-old female presents in this clinic with crusted itchy skin with 5 years of eczematous duration

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07
Oct
0

A Comprehensive Review of the Adverse Effects of Systemic Corticosteroids

Posted by on in Skin Matters

Corticosteroids are commonly prescribed by practitioners in many medical specialties for the treatment of chronic inflammatory conditions. The use of corticosteroids in the treatment of chronic rhinosinusitis is well described and based on their anti-inflammatory effects. The duration of corticosteroid therapy in these conditions is often less than 1 month, in contrast to the treatment of chronic respiratory diseases (ie, asthma, chronic obstructive pulmonary disease) or autoimmune disorders (ie, rheumatoid arthritis, systemic lupus erythematosus, Crohn disease, and ulcerative colitis), which can last for years.

 

Reference:
David M. Poetker, Douglas D. Reh. (2010). A Comprehensive Review of the Adverse Effects of Systemic Corticosteroids.  Otolaryngologic Clinics of North America. 43 (2010) 753–768 doi:10.1016/j.otc.2010.04.003

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07
Oct
0

Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity

Posted by on in Skin Matters

This paper is to search for an effective immunosuppressant from Glycyrrhiza uralensis (Licorice, Gan Cao). Our results show the immunosuppressive activity of glycyrol and this activity should be due to its inhibitory effect on CN activity, thereby suppressing IL-2 production and regulating T lymphocytes. Thus, glycyrol could be a candidate for development as a novel immunomodulatory drug.

 

 

Reference:
Jiayu Li1, Ying Tu1, Li Tong, Wen Zhang, Jianquan Zheng, and Qun Wei. (2010). Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity. Pharmaceutical Biology, 2010; 48(10): 1177–1184

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07
Oct
0

Biologic Therapy and Risk of Infection

Posted by on in Skin Matters

Biologic compounds are being used more frequently to treat a multitude of systemic inflammatory conditions. These novel compounds are composed of antibodies or other peptides that act through one of three mechanisms: inhibiting inflammatory cytokine signaling (typically tumor necrosis factor or TNF), inhibiting T-cell activation, or depleting B-cells. The increase in use and ever expanding list of new immune modulating therapies make knowledge of the infectious complications associated with immune modulation even more important. Of particular concern is the risk for developing atypical and opportunistic infections including tuberculosis, herpes zoster, Legionella pneumophila, and Listeria monocytogenes.

Reference:
Rachel Gordon, Rana Mays, Hung Doan, Whitney Lapolla, Stephen K. Tyring. (2012). Biologic Therapy and Risk of Infection. Skin therapy Letter. Volume 17, Number 4, Aprial 2012. Continue reading
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