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30
Jun

Consequences of systemic absorption of topical glucocorticoids and Evaluation of the pituitary-adrenal axis function in patients on topical steroid therapy

Posted by on in Skin Matters
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In this Volume 65, Issue 1 of the JAAD, Kerner et al report blunted adrenal responses after the use of topical corticosteroids. While it is reassuring that laboratory values remained within the normal range in this particular study, the blunted responses serve as a reminder that systemic absorption of topically applied corticosteroids can have systemic implications. Topical corticosteroids can cause iatrogenic Cushing disease and adrenal suppression. Those at greater risk for medically significant adrenal suppression include infants and young children, those with an impaired cutaneous barrier, and those in whom highly potent corticosteroids are applied over large areas or under occlusion. Highly vascular areas, such as the ear canals and diaper area, have been associated with enhanced...

Consequences of systemic absorption of topical glucocorticoids and Evaluation of the pituitary-adrenal axis function in patients on topical steroid therapy

Reference:
Lynnette K. Nieman. (2011) Consequences of systemic absorption of topical glucocorticoids. Journal of the American Academy of Dermatology. Volume 65, Issue 1 , Pages 250-252

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