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26
Dec
0

Patient-reported reasons for the discontinuation of commonly used treatments for moderate to severe psoriasis

Posted by on in Skin Matters

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A total of 1095 patients with moderate to severe plaque psoriasis from 10 dermatology practices was studied,patients stopped systemic treatments (MTX, Acitretin, Cyclosporine) and phototherapy (UVB and PUVA) after medians of 6 to 12 months and biologic agents (Etanercept, Adalimumab, Infliximab) after medians of 12 to 20.5 months. Side effects and lost efficacy are important limiting factors for treatment persistence.

 

 

Reference:
Howa Yeung, Joy Wan, Abby S. Van Voorhees, Kristina Callis Duffin, Gerald G. Krueger,Robert E. Kalb, Jamie D. Weisman, Brian R. Sperber, Bruce A. Brod, Stephen M. Schleicher, Bruce F. Bebo, Jr, Daniel B. Shin, Andrea B. Troxel, Joel M. Gelfand. (2013). Patient-reported reasons for the discontinuation of commonly used treatments for moderate to severe psoriasis. Journal of the American Academy of Dermatology. 2013;68:64-72.

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Tagged in: Psoriasis
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07
Oct
0

A Comprehensive Review of the Adverse Effects of Systemic Corticosteroids

Posted by on in Skin Matters

Corticosteroids are commonly prescribed by practitioners in many medical specialties for the treatment of chronic inflammatory conditions. The use of corticosteroids in the treatment of chronic rhinosinusitis is well described and based on their anti-inflammatory effects. The duration of corticosteroid therapy in these conditions is often less than 1 month, in contrast to the treatment of chronic respiratory diseases (ie, asthma, chronic obstructive pulmonary disease) or autoimmune disorders (ie, rheumatoid arthritis, systemic lupus erythematosus, Crohn disease, and ulcerative colitis), which can last for years.

 

Reference:
David M. Poetker, Douglas D. Reh. (2010). A Comprehensive Review of the Adverse Effects of Systemic Corticosteroids.  Otolaryngologic Clinics of North America. 43 (2010) 753–768 doi:10.1016/j.otc.2010.04.003

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07
Oct
0

Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity

Posted by on in Skin Matters

This paper is to search for an effective immunosuppressant from Glycyrrhiza uralensis (Licorice, Gan Cao). Our results show the immunosuppressive activity of glycyrol and this activity should be due to its inhibitory effect on CN activity, thereby suppressing IL-2 production and regulating T lymphocytes. Thus, glycyrol could be a candidate for development as a novel immunomodulatory drug.

 

 

Reference:
Jiayu Li1, Ying Tu1, Li Tong, Wen Zhang, Jianquan Zheng, and Qun Wei. (2010). Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity. Pharmaceutical Biology, 2010; 48(10): 1177–1184

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07
Oct
0

Biologic Therapy and Risk of Infection

Posted by on in Skin Matters

Biologic compounds are being used more frequently to treat a multitude of systemic inflammatory conditions. These novel compounds are composed of antibodies or other peptides that act through one of three mechanisms: inhibiting inflammatory cytokine signaling (typically tumor necrosis factor or TNF), inhibiting T-cell activation, or depleting B-cells. The increase in use and ever expanding list of new immune modulating therapies make knowledge of the infectious complications associated with immune modulation even more important. Of particular concern is the risk for developing atypical and opportunistic infections including tuberculosis, herpes zoster, Legionella pneumophila, and Listeria monocytogenes.

Reference:
Rachel Gordon, Rana Mays, Hung Doan, Whitney Lapolla, Stephen K. Tyring. (2012). Biologic Therapy and Risk of Infection. Skin therapy Letter. Volume 17, Number 4, Aprial 2012. Continue reading
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30
Jun
0

Consequences of systemic absorption of topical glucocorticoids and Evaluation of the pituitary-adrenal axis function in patients on topical steroid therapy

Posted by on in Skin Matters

Alert4_iconIn this Volume 65, Issue 1 of the JAAD, Kerner et al report blunted adrenal responses after the use of topical corticosteroids. While it is reassuring that laboratory values remained within the normal range in this particular study, the blunted responses serve as a reminder that systemic absorption of topically applied corticosteroids can have systemic implications.

 

 

 

Reference:
Lynnette K. Nieman. (2011) Consequences of systemic absorption of topical glucocorticoids. Journal of the American Academy of Dermatology. Volume 65, Issue 1 , Pages 250-252

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