What is Acne-like Breakouts? 痤疮样痘痘到底是什么？
Folliculitis is an infammaiton of the superficial or deep hair follicle on hair-bearing skin due to infectious or non-infectious…
Read moreMonthly archives: February, 2020
Midnight Feasts Could Cause Melasma 夜宵也会导致黄褐斑
Overnight, keratinocytes (kind of skin epidermis cell) proliferate rapidly, preparing and protecting our outer barrier…
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Epidermis-Honeycomb-Water Cube 表皮-蜂巢-水立方
130 years ago, Lord Kelvin asked how space might be partitioned into cells of fixed equal volume with minimum surface…
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A Topical Setroid Induced Rosacea 外用类固醇诱导出现酒糟性皮炎
Steroid induced Rosacea: persistent facial erythema and inflammatory papulopustules, additional features are facial telangiectasias,…
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Severe Adverse Events Are Associated with Short Courses of Oral Corticosteroids? 皮质激素长期服用有害，短期如何？
Each year, doctors prescribe courses of oral corticosteroids to three quarters of patients with chronic inflammatory disorders…
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Eczema Allergy — A Question of Immune System Imbalance 湿疹、过敏：一个免疫均衡的问题
过敏反应主要和获得性免疫有关。机体对某些抗原物质初次接触以后产生初次免疫应答，此后便有了免疫记忆，当再次接触相同抗原时，就可触发免疫应答或者导致相应的过敏反应。机体从环境当中获取抗原（比如饮食中的一些蛋白质），抗原成分经过抗原递呈细胞，提取抗原信息，刺激调节性T细胞，从而呈递给T辅助细胞，促使T辅助细胞向Th1或者Th2两条途径发展。如果朝着Th2方向发展，就是过敏反应方向。…
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Steroids Rosacea Overlaps Retinoid Dermatitis 激素性皮炎叠加维A酸皮炎
A 54-year-old woman presented with 3 months of facial rash. The rash persisted despite a recent 2-month applicaiton of…
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Why Mortgage Sicken Us? 为什么房贷会让我们生病？
Glucocorticoids [1] plus the sympathetic nervous system [2] enables an organism to survive a physical stressor by activating…
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Avoid Steroids as a First Line Therapy 避免使用类固醇作为一线疗法
A 40-year-old woman presented with a two-month history of worsening rashes on her chest, arms and legs. Twenty months…
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A Systematic Review of Corticosteroid Withdrawal Syndrome 激素戒断综合征
What is Corticosteroid Withdrawal Syndrome CWS?Steroids Withdrawal Syndrome is a distinct clinical adverse effect of steroid….
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If you know the problem, you have already understood half of it. 如果你知道问题所在，那么就已经理解了一半。
《新英格兰医学杂志》2020年7月9日发表了一篇取名为nemolizumab的生物制剂治疗湿疹的三期临床实验如下：…
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Do we have eczema gene(s) – Time to rethink biologics 关于湿疹基因—生物药的再思考
Do we have eczema gene(s) – Time to rethink
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A 64-year-old man with 15-year history of Prurigo Nodularis 64岁罹患结节性痒疹15年
Chronic pruritus (itch) is defined as ‘an unpleasant sensation leading to the desire to scratch lasting at least 6 weeks…
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gene + environment + triggers + chance = phenotype 基因+环境+触发+概率=表型
Know then thyself, presume not God to scan; The proper study of mankind is man. — Alexander Pope, Essay on Man PAST…
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Trade Agreement between Bacteria, Viruses and Human Skin — A fly in the ointment 细菌、病毒与人皮的经贸协定 — 美中不足的共生
Staphylococcus is a group of Gram-positive cocci. It is named because it appears spherical (cocci) and form in grape-like…
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Secret of the Western science：A little piece in a larger jigsaw 科学秘密：一条大锯上的又一个锯齿
Our present system of scientific communication depends almost entirely on the “primary” literature. This has three…
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Third-degree burn in Type 2 Diabetes II型糖尿病3度烧伤
What is diabetes mellitus? All the human cells need sugar to work normally. Sugar enters into the cells with the help…
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Know the medicine before you take it 皮肤用药三思而后行
The prevalence of immue system related skin disorders such as psoriasis, atopic dermatitis (AD) , and allergy has increased…
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Psoriasis in Children 儿童银屑病
Chronic plaque psoriasis is the most common clinical form of psoriasis in children, approximately one-third reported onset…
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WhatsApp Facebook WeChat Testimonial 患者的回馈见证
We thank patients for sending us the photos via WhatsApp/Facebook and giveing consent for them to be used as testimonial….
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2nd-degree burns healed in 12 days, no scar left 二度烧伤12天治愈不留疤痕
A second-degree, or partial-thickness, burn penetrates into but not through the dermis. Because the epidermal barrier…
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Prurigo Simplex trigged by hair dyes 染发剂激发的单纯痒疹
Prurigo simplex is symmetrically distributed with small intensely itchy papules, which is in dome-shaped and topped with…
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Cosmetics Induced Dermatitis due to Facial Mask 甘草酸苷美白面膜导致的皮炎
Facial whitening masks/creams/gels are used commonly by Asian women who expects the aesthetic effect on their coloured…
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Severe Eczema in a 20-month-old Child 严重幼儿湿疹
The majority of patients with eczema will present with symptoms in childhood, it may starts at any age, even 2 months…
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Creatine Kinase and Rhabdomyolysis 异维A酸（异维甲酸），肌酸激酶与横纹肌溶解症
Isotretinoin Isotretinoin, retinoic acid (form of victamin A) derivative, is used to treat Pimples (Acne), Psoriasis,…
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Occupational Associcated Hand Eczema 职业性手湿疹
手部湿疹的典型临床症状是红疹、皮肤浸润、细小囊泡、脱皮、糜烂、水肿，角化过度，皲裂(Fig.1A)…
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Biologics (4) IL-4Rα Inhibitors 生物制剂之白细胞介素-4受体α抑制剂
What is Interleukin-4 (IL-4) and Interleukin-4 Receptor (IL-4R) IL-4 is produced by T cells. The T cells are kinds of…
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Biologics (3) IL-17 Inhibitors 生物制剂之白细胞介素-17抑制剂
What is Interleukin-17 (IL-17) Interleukin 17 (IL-17 or IL-17A) is produced by T helper 17 (Th17) cells, macrophages,…
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Biologics (2) IL-12/23 Inhibitors 生物制剂之白细胞介素-12/23抑制剂
What is Interleukin 12 (IL-12) Interleukin 12 has two subunits: IL-12A (p35) and IL-12B (p40). The IL-12 is produced by…
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Biologics (1) Tumor Necrosis Factor Inhibitors 生物制剂之肿瘤坏死因子抑制剂
What is “biologic” agent? Whole immune system suppression will cause serious side effects. Therefore “biologic”…
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Think Different! 医学不是只有一种呈现方式，我们坚信应该以不同的方式思考。我们是把治疗方案设计得安全、简单、有效。
Conventionally eczema patients will be given corticosteroids to shut down the inflammation, then use aggressive moisturiser…
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This is How Psoriasis Biologics are Performing in the Real World 治疗银屑病的生物抑制剂在真实世界的表现
Real-world risks of serious infection, major cardiovascular events, and cancers have been looked at in the observational…
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Trade-offs Between Risks and Benefits of Drug Treatment for Skin Diseases 用这些药物治疗皮肤病值得吗？
A 25-year-old woman presents with redness of the hands and reports the intermittent occurrence of tiny vesicles, and scaling,…
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Facial Erosive Pustular Dermatosis After Cosmetic Resurfacing 激光技术镭射磨皮导致面部糜烂性脓疱性皮肤病
Importance Erosive pustular dermatosis (EPD) is a rare condition that typically affects actinically damaged skin of…
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Induction of Rosaceiform Dermatitis With Tacrolimus (Protopic) Ointment 他克莫司(普特皮)乳膏激发红斑痤疮样颜面皮炎
Tacrolimus is an immunosuppressive macrolide that acts by blocking the calcineurin-dependent signal transduction pathway…
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A 60-Year-Old Man with Severe Hyperkeratotic Palmoplantar Eczema 掌跖角化过度型湿疹
A 60-year-old man presents with hyperkeratosis and cracking of the skin on the palms of his hands and the soles of his…
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强效抑制剂替代弱效，一种疾病治成多种疾病，医学陷入了死循环
一名56岁的退休行政人员被转诊至皮肤科，以寻求有关终身性特应性皮炎管理的第二种意见。她已经连续10年每天两次在自己的脸上涂抹1％的氢化可的松霜（弱效皮质激素），在身体其他皮肤部位使用戊酸倍他米松软膏（强效皮质激素）。她还患有过敏性哮喘，过去11年来每天两次，用倍氯米松双丙酸倍氯米松（皮质激素）雾化吸入控制哮喘，并已经按照医生处方口服12个疗程的（皮质激素）泼尼松龙（每个疗程平均剂量为30毫克，连续5天），以治疗湿疹和湿疹{1]。…
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Lupus Miliaris Disseminatus Faciei 颜面粟粒性播散性狼疮
Lupus Miliaris Disseminatus Faciei Firm, yellowish-brown, 1–3 mm, monomorphous, discrete, smooth-surfaced papules present…
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How Alcohol Affect Psoriasis?为什么喝酒会加重银屑病(牛皮癣)？
In contrast to the microvasculature of normal skin, the psoriatic microvasculature is characterized by tortuous and leaky…
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What is Atopy? 什么是特异性atopic？
The terms “dermatitis” and “eczema” are frequently used interchangeably. When the term “eczema”…
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