Overnight, keratinocytes (kind of skin epidermis cell) proliferate rapidly, preparing and protecting our outer barrier for the sunlight and scratches of the coming day. During the day, these cells then selectively switch on genes involved with protection against the sun’s ultraviolet (UV) rays….
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130 years ago, Lord Kelvin asked how space might be partitioned into cells of fixed equal volume with minimum surface area [1]? Although his work was dismissed as “a pure waste of time” by his colleagues, he worked out through intensive calculation and proposed a fourteen-face shape (tetradecahedron)…
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Each year, doctors prescribe courses of oral corticosteroids to three quarters of patients with chronic inflammatory disorders (1) and up to 17% of the general population (2). Most of these will be short “bursts” of 1 or 2 weeks, typically prescribed for common ailments like upper respiratory…
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过敏反应主要和获得性免疫有关。机体对某些抗原物质初次接触以后产生初次免疫应答，此后便有了免疫记忆，当再次接触相同抗原时，就可触发免疫应答或者导致相应的过敏反应。机体从环境当中获取抗原（比如饮食中的一些蛋白质），抗原成分经过抗原递呈细胞，提取抗原信息，刺激调节性T细胞，从而呈递给T辅助细胞，促使T辅助细胞向Th1或者Th2两条途径发展。如果朝着Th2方向发展，就是过敏反应方向。…
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Glucocorticoids [1] plus the sympathetic nervous system [2] enables an organism to survive a physical stressor by activating the classical “fight or flight” response. The stress response rapidly mobilizes energy into circulation from storage sites in your body. Furthermore, heart rate and blood…
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What is Corticosteroid Withdrawal Syndrome CWS?Steroids Withdrawal Syndrome is a distinct clinical adverse effect of steroid. It is also called facial corticosteroid addictive dermatitis, red skin syndrome, topical corticosteroid induced rosacea-like dermatitis, steroid addiction syndrome, steroid…
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《新英格兰医学杂志》2020年7月9日发表了一篇取名为nemolizumab的生物制剂治疗湿疹的三期临床实验如下： 给一组患者注射nemolizumab，另一组注射安慰剂。注意⚠️：这里才是重点：在两组患者用药期间同时使用中等效力的外用糖皮质激素、外用钙调磷酸酶抑制剂和口服抗组胺药。这项研究还允许研究人员使用较高效力的外用糖皮质激素给于那些湿疹加重的患者。…
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Do we have eczema gene(s) – Time to rethink
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Know then thyself, presume not God to scan; The proper study of mankind is man. — Alexander Pope, Essay on Man PAST Several genome‐wide association studies (GWAS) [1-13] have been reported and provide evidence for over 40 genes involved in psoriasis causation (Table 1. Psoriasis susceptibility…
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Staphylococcus is a group of Gram-positive cocci. It is named because it appears spherical (cocci) and form in grape-like clusters [1-4] under the microscope. Staphylococci live all over us, and seem to have adapted to conditions in our skin that are uncongenial to most other bacteria [1,4-6]….
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