Biologics (3) IL-17 Inhibitors 生物制剂之白细胞介素-17抑制剂

What is Interleukin-17 (IL-17)

Interleukin 17 (IL-17 or IL-17A) is produced by T helper 17 (Th17) cells, macrophages, dendritic cells (DC) and natural killer to against infections such as AIDS, malaria, and tuberculosis. The T cells, macrophages, dendritic cells (DC) and natural killer are kinds of immune system white blood cells, they locate and ‘eat’ harmful particles such as bacteria, viruses, fungi, and parasites. [1,2]

Depleted IL-17 cause extracellular bacterial and fungi infections.[3]

Elevated IL-17 level is linked with immune-mediated diseases, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, inflammatory bowel disease. [1,4,5]

Interleukin-17 Inhibitors

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Three IL-17 inhibitors have been approved for the treatment of psoriasis: ixekizumab and secukinumab, which target IL-17A, and brodalumab, which blocks the IL-17 receptor A. [6]

 

Reference:

  1. Gaffen SL. An overview of IL-17 function and signaling. Cytokine. 2008;43(3):402–407. doi:10.1016/j.cyto.2008.07.017
  2. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol. 2009; 27():485-517.
  3. Yang B, Kang H, Fung A, Zhao H, Wang T, Ma D. The role of interleukin 17 in tumour proliferation, angiogenesis, and metastasis. Mediators Inflamm. 2014;2014:623759. doi:10.1155/2014/623759
  4. IL17A interleukin 17A [ Homo sapiens (human) ] Gene ID 3605 https://www.ncbi.nlm.nih.gov/gene/3605
  5. INTERLEUKIN 17A; IL17A https://omim.org/entry/603149
  6. Jean L. Bolognia , Julie V. Schaffer , Lorenzo Cerroni, edit. Dermatology, Fourth edition, China: Elsevier, 2018, ISBN 978–0‐7020–6275–9. page2251-2253