Fissured Tongue 沟裂舌
Fissured tongue is a common, benign clinical condition of unknown etiology that affects more than 2-30% the population. Heredity appears to be a factor, with some evidence suggesting that the condition represents a polygenic trait, or an autosomal dominant trait with incomplete penetrance or expressivity.
Fissured tongue is often found in association with geographic tongue, suggesting that the same gene or genes may be associated with both conditions. Fissured tongue may be a component of the Melkersson–Rosenthal syndrome. It is a common finding in Down syndrome and is occasionally seen in association with Cowden syndrome, pachyonychia congenita, and acromegaly (in the setting of macroglossia). There is an occasional association with psoriasis and reports of improvement during infliximab treatment for psoriasis.
沟裂舌是一种常见的良性临床病症,病因不明,影响人口的2-30%。遗传似乎是一个因素,一些证据表明该病症代表多基因性状,或具有不完全外显率或表达性的常染色体显性遗传。经常发现裂隙舌与地图舌同时出现,表明相同的基因可能与这两种情况相关。沟裂舌可能是Melkersson-Rosenthal综合征的一个组成部分,也是唐氏综合症的常现,也在Cowden综合征出现,也与先天性厚皮病和肢端肥大症相关。也有报道在牛皮癣患者中出现。
Reference:
- N Yarom, U Cantony, M Gorsky: Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. Dermatology. 209:88-94 2004
- Kullaa‐Mikkonen A, Sorvari T, Kotilainen R, et al. Morphological variations on the dorsal surface of the human tongue. Proc Finn Dent Soc 1985;81:104–10.
- Kalifatidis A, Albanidou‐Farmaki E, Daniilidis M, Markopoulos AK, Karyotis N, Antoniades DZ. HLA alleles and fissured tongue. Int J Immunogenet 2010 Dec;37(6):509–11.
- D’Erme AM, Agnoletti AF, Prignano F. Fissured tongue responding to biologics during the treatment of psoriasis: the importance of detecting oral involvement of psoriasis. Dermatol Ther 2013 Jul–Aug;26(4):364–6.