How Alcohol Affect Psoriasis?为什么喝酒会加重银屑病(牛皮癣)？

In contrast to the microvasculature of normal skin, the psoriatic microvasculature is characterized by tortuous and leaky blood vessels that facilitate leukocyte migration into inflamed skin. The vascular endothelial growth factor (VEGF) and angiopoietins are some of the factors believed to be responsible for these vascular changes in psoriasis. Evidence of a role of endothelial cells in psoriasis includes the increased expression of vascular endothelial growth factor (VEGF)[1], psoriasiform inflammation in mouse models with transgenic overexpression of VEGF in the epidermis, the association of psoriasis with VEGF gene variants [2], and the efficacy of drugs targeting angiogenesis in animal models [3].

Moderate alcohol consumption is considered to be approximately one to two drinks per day. One standard drink is defined as 360 ml beer, 150 ml wine, or 45 ml liquor, each containing ∼15 g of ethanol. The epidemiological studies show that moderate consumption of alcohol reduces the risk of coronary heart disease, sudden cardiac death, and ischemic stroke, however, the mechanisms for these reductions in cardiovascular disease are not well established. The results of the present study [4,5] indicate that alcohol induce expression of vascular endothelial growth factor VEFG and stimulate angiogenesis, which are be responsible for psoriatic vascular change.

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Any type of alcoholic beverage, beer, wine, liqure, does has a negative impact on psoriasis. Therefore, the type doesn’t matter when it comes to the relationship between alcohol and psoriasis. Our studies show that men who drink alcohol don’t respond to psoriasis treatments well, and some patients who drink heavily find that their skin gets better when they stop. During our herbal treatment, patients advised to stay away from alcohol completely.

 

Reference:

  1. Detmar M, Brown LF, Claffey KP, et al. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med1994;180:1141–1146
  2. Young HS, Summers AM, Read IR, et al. Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis. J Invest Dermatol 2006;126:453–459
  3. Halin C, Fahrngruber H, Meingassner JG, et al. Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol 2008;173:265–277
  4. Gu, J.-W., Elam, J., Sartin, A., Li, W., Roach, R., & Adair, T. H. (2001). Moderate levels of ethanol induce expression of vascular endothelial growth factor and stimulate angiogenesis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 281(1), R365–R372.
  5. Jones, M.K., Itani, R.M., Wang, H., Tomikawa, M., Sarfeh, I.J., Szabo, S. and Tarnawski, A.S., 1999. Activation of VEGF and Ras genes in gastric mucosa during angiogenic response to ethanol injury. American Journal of Physiology-Gastrointestinal and Liver Physiology, 276(6), pp.G1345-G1355.