• • NOVEMBER 19, 2019

  Biologics (2) IL-12/23 Inhibitors 生物制剂之白细胞介素-12/23抑制剂

  What is Interleukin 12 (IL-12)

  Interleukin 12 has two subunits: IL-12A (p35) and IL-12B (p40). The IL-12 is produced by macrophages, monocytes and B lymphocytes to against infections such as AIDS, malaria, and tuberculosis. The macrophages, monocytes and B lymphocytes are kinds of immune system white blood cells, they locate and ‘eat’ harmful particles such as bacteria, viruses, fungi, and parasites. [1,2]

  IL-12 is essential for protective immunity to intracellular bacteria such as mycobacteria and salmonella. [3]

  Impaired IL-12 causes immunodeficiencies. [4]
  Elevated IL-12 is linked with immune-mediated diseases, psoriasis, psoriatic arthritis, Crohn’s disease, multiple sclerosis. [5]

  What is Interleukin 23 (IL-23)

  Interleukin 23 has two subunits: IL-23A (p19) and IL-23B (p40). The IL-23 is produced by dendritic cells and macrophages. The macrophages and dendritic cells are kinds of immune system white blood cells, they locate and ‘eat’ harmful particles such as bacteria, viruses, fungi, and parasites.

  Elevated IL-23 is linked with immune-mediated diseases, psoriasis. [6]

  IL-12/23 Inhibitors / IL-23 Inhibitors

  

  Ustekinumab (Stelara ® ) is a monoclonal antibody that targets IL-12 and IL-23, whereas guselkumab (Tremfya TM ), risankizumab, and tildrakizumab are monoclonal antibodies that target IL-23. [7]

   

  Reference

  1. IL-12A (p35) https://omim.org/entry/161560
  2. IL-12B (p40) https://omim.org/entry/161561
  3. Altare, F., Lammas, D., Revy, P., Jouanguy, E., Doffinger, R., Lamhamedi, S., Drysdale, P., Scheel-Toellner, D., Girdlestone, J., Darbyshire, P., Wadhwa, M., Dockrell, H., Salmon, M., Fischer, A., Durandy, A., Casanova, J.-L., Kumararatne, D. S. Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection. J. Clin. Invest. 102: 2035-2040, 1998.[PubMed: 9854038]
  4. INTERLEUKIN 12B; IL12B, OMIM 161561 https://omim.org/graph/linear/161561
  5. IL12B interleukin 12B [ Homo sapiens (human) Gene ID: 3593 https://www.ncbi.nlm.nih.gov/gene/3593
  6. INTERLEUKIN 23-ALPHA; IL23A OMIM gene 605580 https://omim.org/entry/605580
  7. Jean L. Bolognia , Julie V. Schaffer , Lorenzo Cerroni, edit. Dermatology, Fourth edition, China: Elsevier, 2018, ISBN 978–0‐7020–6275–9. page2251-2253

  • Skin Matters

By Tony Tang Yuqi

Physician Tony Tang Yuqi leads Tangs Clinical TCM with a wealth of knowledge and experience. Holding esteemed qualifications such as an MSc in Clinical Research from Edinburgh and an MBA from Singapore, alongside a Diploma in Traditional Chinese Medicine and registration as a TCM Physician in Singapore. He believes in a compassionate and holistic approach to healthcare, especially when it comes to TCM treatment for eczema, providing comprehensive patient care.