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The Tangs Psoria range comprises five formulas. These are not five stages taken in sequence — they are five formulas for different constitutions and presentations.

Psoriasis is known in Chinese medicine as bai bi. Classical physicians related the dryness, scaling and persistence of the lesions to heat and dryness in the blood, and to insufficient yin and blood failing to nourish the skin. Most formulas in this range work by nourishing yin, cooling the blood and relieving dryness, with a lighter dispersing action for wind-heat. One formula takes the opposite approach, yang warming and moving, for those whose lesions are dark and dull and who feel worse in cold weather.

Your physician assesses the colour, dryness, thickness and duration of your lesions together with your constitution, digestion, perspiration and sleep, identifies the current pattern, and selects the formula and dose accordingly. As the pattern changes, the formula changes with it.

These are prescription formulas and require consultation and pattern diagnosis by a physician.

Conditions Commonly Managed 

Psoriasis (Plaque Psoriasis, Guttate Psoriasis, Inverse Psoriasis, Pustular Psoriasis), Eczema (Atopic Dermatitis), Palmoplantar Pustulosis (PPS), Acrodermatitis continua (Hallopeau disease)

Not offered as first-line care: generalised pustular psoriasis, erythrodermic psoriasis, and acrodermatitis continua of Hallopeau are potentially life-threatening dermatological emergencies. Patients with these forms must be assessed by, and remain under the care of, a registered dermatologist. Tangs Psoria is not offered as an alternative to emergency or specialist medical care.

Contraindications

Do Not Take Together With:

Corticosteroids and other immunosuppressants, both conventional and herbal (including UVB and PUVA phototherapy). Full list Corticosteroids or immunosuppressive drugs. (Herbal and Conventional)

Commonly overlooked items on that list include fish oil, flaxseed oil, evening primrose oil, turmeric, resveratrol, chia seeds, cordyceps, Centella asiatica and cassia seed. Please tell us everything you are taking, including supplements and health foods.

Do Not Take Tangs Psoria If You:

  • are pregnant
  • are taking warfarin or any other anticoagulant or antiplatelet medication — this formula contains Radix Salviae Miltiorrhizae (Danshen), which may increase bleeding risk
  • have a known allergy to any ingredient listed below
  • have significant liver or kidney impairment, unless cleared by your doctor

Stop and Seek Medical Attention If:

Fever with widespread pustules; rapidly spreading redness over most of the body; jaundice or dark urine; unusual bruising or bleeding; difficulty breathing or facial swelling.

Estimated Recovery Peroid 治愈时间

  • The time to recovery is much longer and more unpredictable for patients with a history of immunosuppressant use. A retrospective observational study shown that the effectiveness of Tangs was inversely associated to prior immunosuppressants exposure (r = 0.9154): the complete clearance was achieved in 8 months (87.5%, 14 of 16) in non-immunosuppressants subjects; the wavelike evolution of psoriatic lesion appeared in prior immunosuppressants subjects, time required to recover is proportionate to the time immunosuppressants were used. In our clinical experience the frequency and severity of flares during treatment, and the time to settle, increase with the type, dose, potency and duration of the immunosuppressive agents previously used — both topical and systemic. Topical corticosteroids used more often, for longer, over a larger area, or at higher potency are associated with a slower course. These are observations from clinic follow-up, not controlled data, and individual response varies. Please book a consultation for an assessment of your own situation.
  • 有用过免疫抑制剂者:  治疗过程中反复的频率与程度、以及完全消退所需时间，与既往使用的免疫抑制剂（外用及全身）种类、剂量、强度和使用时长相关——使用越频繁、时间越长、面积越大、效能越强，所需时间通常越长。以上为门诊随访观察，非对照研究数据，个体差异较大，具体情况请预约面诊评估。

Prognosis of the Immunosuppressants Withdraw Syndrome:
波浪式反复(免疫抑制剂反弹症)

Tangs Psoria is not given alongside corticosteroids or other immunosuppressants. Where a patient is already receiving such treatment, any change must be planned and supervised by the doctor who prescribed it. Systemic corticosteroids in particular must never be stopped abruptly: abrupt withdrawal can cause adrenal insufficiency, and in psoriasis can trigger a generalised pustular or erythrodermic flare. We will not begin herbal therapy until a withdrawal plan has been agreed with the prescribing doctor. Patients with a history of immunosuppressant use will likely start to experience the so-called Wavelike Flare-up Cycle (above figure). This is known as the Immunosuppressant Withdrawal Syndrome. Symptoms of psoriasis which had previously been suppressed by immunotherapy will start to resurface with vigor after the immune system is no longer being curtailed. Over time, as Tangs Psoria gradually takes effect in correcting the immune system’s function, the flareups will subside in frequency and intensity in a wavelike pattern (above figure). The time to reach the endpoint where the wave draws to a null will depend on the dosage and potency of the immunosuppressants that the user had formerly consumed.

Description of Criterion for the Curative Progress
治愈标准

  • As lesions settle, previously affected areas often remain lighter than the surrounding skin. This is post-inflammatory hypopigmentation and is an expected part of healing; skin tone generally evens out over the following months as the epidermis renews (See Fig. Panel.D).
  • Some patients have remained clear for extended periods after stopping herbal treatment. The first patient ever treated with TANGS treatment in 1980, has not experienced a relapse to this day – a 30-year period. These are individual observations recorded during clinic follow-up, not controlled outcome data, and they do not predict the course of any other patient. Psoriasis is currently regarded in modern medicine as a chronic relapsing condition for which no cure is established. We make no claim that Tangs Psoria cures psoriasis or prevents relapse.

 

Diagram of the Recovery Processs
治疗过程图解

 

Dosage

3000mg to be taken two times daily

Precaution

  • During the course of Tangs Psoria therapy, abstain from all immunosuppressants and oral contraceptive pills. Abstain from alcohol consumption and avoid late nights. Avoid hot baths, and do not aggravate the skin by scratching or peeling the psoriatic lesions. A more relaxed lifestyle is recommended.
  • Commonly overlooked items on that list include fish oil, flaxseed oil, evening primrose oil, turmeric, resveratrol, chia seeds, cordyceps, Centella asiatica and cassia seed. Please tell us everything you are taking, including supplements and health foods.
  • 皮质类固醇等免疫抑制剂药物 (包括UVB和PUVA) 和植物类免疫抑制剂药物 (甘草,白鲜皮,蝉蜕,大黄,金银花,雷公藤等),口服避孕药,饮酒,熬夜,刺激癣疹(搔抓搓),精神情绪不稳定,热水洗浴.
  • have a known allergy to any ingredient listed below／对下列任一成分已知过敏

Ingredients

Tangs Psoria-1, each 360mg extract equivalent to 2354mg raw herbs:
Rhizoma Zingiberis [1-10] 429mg
Radix Paeoniae Alba [11-19] 156mg
Radix Astragali [20-22] 313mg
Radix Salviae Miltiorrhizae [23-27] 556mg
Ramulus Cinnamomi [28-33] 299mg
Semen Coicis [34-40] 538mg
Radix Codonopsis [41-46] 63mg

Tangs Psoria-2, each 360mg extract equivalent to 1500mg raw herbs:
Radix Rehmanniae [47-55] 400mg
Radix Scrophulariae [56-62] 400mg
Radix Codonopsis [41-46] 80mg
Fructus Lycii [63-66] 120mg
Flos Chrysanthemi [67-70] 500mg

Tangs Psoria-3, each 360mg extract equivalent to 2030mg raw herbs:
Radix Rehmanniae [47-55] 420mg
Radix Scrophulariae [56-62] 420mg
Radix Codonopsis [41-46] 80mg
Flos Chrysanthemi [67-70] 380mg
Folium Mori [71,72] 380mg
Fructus Lycii [63-66] 350mg

Tangs Psoria-4, each 360mg extract equivalent to 2263mg raw herbs:
Radix Astragali [20-22] 313mg
Radix Rehmanniae [47-55] 420mg
Radix Scrophulariae [56-62] 420mg
Flos Chrysanthemi [67-70] 380mg
Folium Mori [71,72] 380mg
Fructus Lycii [63-66] 350mg

Tangs Psoria-5, each 360mg extract equivalent to 2399mg raw herbs:
Radix Rehmanniae [47-55] 333mg
Radix Adenophorae [73,74] 333mg
Fructus Ligustri Lucidi [75-78] 600mg
Fructus Lycii [63-66] 600mg
Flos Chrysanthemi [67-70] 333mg
Fructus Gardeniae [79-82] 100mg
Folium Mori [71,72] 100mg

Clinical Evidence

Rhizoma Zingiberis [1-10]: (dried ginger) — the two studies performed on dried ginger as such point in opposite directions. Dried ginger extract restores Th1/Th2 balance in immunocompromised mice, normalising IFN-γ and Th2 cytokine responses [1]; a neutral glucan isolated from Zingiberis Rhizoma is pro-inflammatory, upregulating IL-6, IL-1β, TNF-α and reactive oxygen species in RAW264.7 cells via TLR4/IKKβ/NF-κB [2]. The remaining evidence is compound-level: ginger phenylpropanoids suppress IL-1β, PGE2 and thromboxane B2 in human whole blood and monocytes by inhibiting iPLA2 and cPLA2 [3]; 6-gingerol and 6-shogaol inhibit human monocyte-derived dendritic cell responses to TLR ligands via NF-κB, MAPK and mTOR, 6-shogaol being the more potent and additionally engaging AMPK and NRF2 [4]; gingerols reach measurable plasma concentrations after oral intake [5]; and IKKβ inhibition with M1-to-M2 repolarisation is summarised in [6-8], with further TLR4-dependent effects in monocytes in [9,10].

Radix Paeoniae Alba [11-19]: suppresses Th2 cell-mediated responses — reduced serum IgE, decreased IL-4/IFN-γ ratios, reversal of Th2 skewing — and inhibits mast cell activation [11,12]. Paeoniflorin and total glucosides of paeony act on NF-κB, MAPK, PI3K/Akt and JAK/STAT signalling [13-15], and in rheumatoid arthritis, experimental autoimmune encephalomyelitis and atopic dermatitis models reduce disease severity and promote immune tolerance by shifting Th1/Th2 activity [16,17].

Radix Astragali [20-22]: flavonoids suppress Th1 and Th17 differentiation and cytokine production (IFN-γ, IL-17) while promoting Treg differentiation, via JAK/STAT and NF-κB signalling [20,21]. Other work reports the opposite direction — increased IL-4 and reduced IFN-γ indicating Th2 polarisation, together with increased CD8 expression supporting cytotoxic T cell activation [22].

Radix Salviae Miltiorrhizae [23-27]: tanshinones I and IIA suppress Th1 differentiation by inhibiting STAT3/STAT5 phosphorylation, reducing IFN-γ production [23,24]. Salvianolic acid A and tanshinone IIA decrease Th2 cytokines (IL-4, IL-13) in allergic models [25]. Polysaccharides promote Treg differentiation and enhance CD8+ T cell cytotoxicity; those findings come from tumour-bearing mice and cancer patients [26,27].

Ramulus Cinnamomi [28-33]: the evidence is anti-inflammatory in direction. Ramulus Cinnamomi essential oil, in which (E)-cinnamaldehyde is roughly 65% of content, inhibits N-acylethanolamine acid amidase, preventing degradation of PEA and OEA and reducing nitric oxide and TNF-α in LPS-stimulated macrophages [28]. In collagen-induced arthritis, Cinnamomi Ramulus extract reduced paw volume, arthritis index and TNF-α, IL-17A, IL-6 and IL-1β, implicating the TNF and IL-17 pathways and NF-κB p65 [29]. An ethanol extract blocks Src/Syk-mediated NF-κB activation [30], and cinnamaldehyde suppresses macrophage cytokine output only in the presence of activated T cells, by eliminating reactive oxygen species [31].

Semen Coicis [34-40]: the effect depends on which fraction is studied. A (1→6)-α-glucan and a branched fructoglucan inhibit LPS-induced inflammation in RAW264.7 macrophages and reduce acute inflammatory swelling in vivo [34], and structure-dependent immunomodulatory, antioxidant and microbiota-regulatory activities of Coix polysaccharides are reviewed in [35-37]. The phenolic constituent coixol suppresses the HSP70/TLR4/NF-κB pathway in hepatic macrophages, reducing HMGB1, TNF-α and iNOS [38], and in colitis modulates macrophage polarisation, elevates Axin1 to promote β-catenin degradation, and expands colonic ILC3 driving IL-22-dependent mucosal healing — an effect abolished by IL-22 neutralisation [39]. Coix seed oil, a lipid extract distinct from the whole raw seed used here, inhibits Th17 differentiation by reducing the leptin–PPARγ interaction [40].

Radix Codonopsis [41-46]: polysaccharides maintain homeostasis of CD4+ and CD8+ T cells, Th1, Th2, Treg and Th17 populations in murine immunosuppression models, stabilising the CD4/CD8 ratio and modulating TNF-α, IL-1β and IL-10 [41-43]. Polyacetylenol glycosides inhibit nitric oxide production and decrease TNF-α and IL-6 in vitro [45,46]. In imiquimod-induced psoriasis in mice, Codonopsis polysaccharide delivered as a microneedle patch with antioxidant polyphenol nanoparticles attenuated inflammation through inhibition of the IL-23/IL-17 axis [44].

Radix Rehmanniae [47-55]: (raw Rehmannia) — the evidence runs in two directions. Polysaccharide and glycoside fractions enhance lymphocyte proliferation and dendritic cell activation with increased IL-2 and IFN-γ in immunosuppression and irradiation models [47,48,50,51,55] — an immune-enhancing direction obtained in models where enhancement is the desired endpoint. Topical extract suppresses Th2-mediated inflammation in atopic dermatitis models, reducing IL-4, serum IgE and histamine [52]; that was topical, not oral, and [53] used a liver injury model. In psoriasis specifically, network pharmacology with experimental validation indicates that aucubin and related compounds downregulate TNF-α, IL-6 and IL-1β and inhibit p38MAPK signalling, a pathway implicated in Th1, Th17 and Th22 activation [54].

Radix Scrophulariae [56-62]: the polysaccharide and iridoid fractions act in opposite directions. Four polysaccharide fractions (SRPs40–100) enhance macrophage pinocytic activity and NO and TNF-α production, raise IL-1β, IL-6, TNF-α and PTGS2 mRNA and TLR2 expression, and increase phosphorylation of p38, ERK, JNK, p65 and IκB; anti-TLR2 antibody abolishes the response, confirming TLR2-driven MAPK and NF-κB activation — an immunostimulatory action [56]. Conversely, crude polysaccharide extract of S. ningpoensis reduced IL-6 and TNF-α dose-dependently in LPS-stimulated mice [57], and the iridoid scropolioside B — isolated from a related Scrophularia species rather than from S. ningpoensis itself — blocked TNF, IL-1β and IL-32 expression through NF-κB inhibition (IC50 1.02 μmol/L) and lowered NLRP3 inflammasome expression, outperforming the structurally related catalpol, which lacked NF-κB inhibitory activity [58]. Iridoid and phenylpropanoid glycosides act synergistically on immune biomarkers [59]; broader phytochemistry and pharmacology are reviewed in [60-62].

Fructus Lycii [63-66]: flavonoids including quercetin inhibit TNF-α, MCP-1 and IL-1β production and downregulate ICAM-1 and VCAM-1 in LPS-stimulated endothelial cells [64]; Lycium barbarum polysaccharides show broad immune-modulating and antioxidant activity [63,66]. [65] is a family-level review of Solanaceae berries.

Flos Chrysanthemi [67-70]: has demonstrated antiallergic effects by inhibiting antigen-induced degranulation and scratching behaviour in mice [69]. Its flavonoids, phenolic acids and polysaccharides suppress IL-1β, IL-6 and IL-8, inhibit oxidative stress and modulate macrophage and mast cell activity in vitro and in animal models [67,68].

Folium Mori [71,72]: the available evidence concerns immune enhancement. Two purified polysaccharide fractions, MLP-1 (9.31×10⁴ Da) and MLP-2 (2.22×10⁶ Da), stimulate proliferation of mouse splenic lymphocytes in vitro, MLP-2 the more active; in chickens immunised with Newcastle disease vaccine, oral MLP-2 raised serum antibody titres and increased IL-2, IFN-γ and secretory IgA in tracheal and jejunal lavage fluid [71]. Structural characterisation and the wider activity profile — hypoglycaemic, antioxidant, immunoregulatory and anticoagulant — are surveyed in [72].

Radix Adenophorae [73,74]: the available evidence is from airway rather than skin models. In an ovalbumin-induced murine model of asthma it suppressed T cell activity, eosinophilia and bronchial hyperresponsiveness [73]; Adenophorae Radix powder also showed antitussive, expectorant and anti-inflammatory activity in mice [74].

Fructus Ligustri Lucidi [75-78]: downregulates IL-17, TNF and IL-1β in murine colitis and diabetic nephropathy models, where oral administration reduced tissue inflammation and improved epithelial integrity [75,76]. Network pharmacology and molecular docking indicate that it targets theIL-17 and TNF signalling pathways [77] — the pathways targeted by IL-17 and TNF inhibitors in psoriasis, making this the most directionally relevant finding for this indication. Immunomodulatory compounds have also been isolated by bioactivity-guided fractionation [78].

Fructus Gardeniae [79-82]: in murine atopic dermatitis models, Gardenia jasminoides extract improved barrier function, reduced dermatitis scores and scratching, and suppressed Th2 cytokines, serum IgE, chemokines and mast cell infiltration [79-81]. Geniposide downregulates Th17 cytokines and upregulates Treg-associated cytokines in non-dermatological models [82].

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