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Tangs Topical Cream

1. Yufu Cream

Active ingredients:

  • Taraxacum Mongolicum Extract [1-8]
  • Aloe Vera Extract [9-18]
  • Camellia Sinensis Extract [19-24]
  • Opuntia Dillenii Extract [25-30]
  • Radix Angelicae Dahuricae Extract [31-35]
  • Houttuynia Cordata Thunb Extract [36-38]
  • Mentha Arvensis Extract [39-41]

2. Lite Balm

Active ingredients:

  • Camellia Sinensis Extract [19-24]
  • Opuntia Dillenii Extract [25-30]
  • Radix Angelicae Dahuricae Extract [31-35]
  • Mentha Arvensis Extract [39-41]

3. HLQ Ointment

Active ingredients:

  • Borneolum Syntheticum [42-49]
  • Radix Scutellariae [50-55]
  • Calamine [56-58]

4. H2 Cream

Active ingredients:

  • Boswellia sacra [59-66]
  • Commiphora myrrha [67-71]
  • Gypsum Fibrosum [72,73]
  • Gypsum Ustum [74]
  • Zinc [75-84]
  • Calamine [56-58]

How to Use

  • Apply over the affected area.
  • Moisturises and protects skin.
  • Store below 30 °C.

Precautions

  • For external use only.
  • Do not use if you have a known allergy to any ingredient listed above.
  • Discontinue and seek medical attention if burning, stinging, increasing redness, swelling, blistering or rash occurs.
  • These creams are not corticosteroids and are not a substitute for medical treatment of infected or rapidly worsening skin.

Ingredient Research

Taraxacum Mongolicum Extract [1-8]: all eight studies are on Taraxacum mongolicum itself. Its flavonoids, phenolic acids, sesquiterpene lactones and polysaccharides modulate TLR2-NF-κB/MAPK and TLR4/IKK/NF-κB signalling and PI3K/Akt/mTOR, reducing pro-inflammatory mediators [5,6,7], and enhance antioxidant defences [1-4]. Most directly relevant here, in DNCB-induced atopic dermatitis in mice it reduced dermatitis-like symptoms while regulating oxidative stress, MAPK and JAK/STAT/TSLP signalling [8].

Aloe Vera Extract [9-18]: acemannan, anthraquinones and polysaccharides upregulate TGF-β, VEGF and IGF-1, stimulate keratinocyte proliferation and migration via EGFR/PKC signalling, and enhance extracellular matrix deposition [9,11,12]. Topical application accelerated wound healing and remodelling in animal studies [13], with antioxidant and antimicrobial activity reported [16]. A Cochrane review of acute and chronic wounds found the clinical evidence inconsistent and called for larger trials with standardised preparations [17] — the most reliable human evidence cited here, and it is equivocal. [10] is a genus-level study, [14] used oral rather than topical administration, and [15] tested a hydrogel dressing.

Camellia Sinensis Extract [19-24]: polyphenols, chiefly epigallocatechin gallate, reduce pro-inflammatory cytokines, scavenge reactive oxygen species and enhance angiogenesis and collagen deposition [19]. Animal studies show accelerated wound closure, improved re-epithelialisation and increased collagen and fibronectin with topical application [20,21], and regulation of hypoxia-responsive microRNAs [22]. Leaf extract shows pleiotropic effects on skin health parameters [24]. [23] tested an EGCG-cerium complex in a hydrogel dressing.

Opuntia Dillenii Extract [25-30]: opuntiol and opuntioside, isolated from the cladode, are dual COX/LOX inhibitors and suppress reactive oxygen species and cytokine production, reducing TNF-α, IL-1β, IL-6, PGE2 and LTB4 [27]. Aqueous extract shows analgesic and anti-inflammatory activity [28], with antioxidant and antibacterial activity attributed to its phenolic content [29,30], and polysaccharide structure and bioactivity are reviewed in [26].

Radix Angelicae Dahuricae Extract [31-35]: in diabetic and infected wound models, Angelica dahurica accelerates wound closure by enhancing neovascularisation via HIF-1α/PDGF-β and PI3K/AKT signalling and increasing endothelial proliferation, migration and tube formation [31,32]. It also drives macrophage polarisation toward the M2 phenotype, with downregulation of TNF-α, IL-6 and IL-1β [33]. Antimicrobial activity against Staphylococcus aureus was shown in a two-herb preparation combining this herb with Rheum officinale [35], and [34] tested a multi-herb mixture.

Houttuynia Cordata Thunb Extract [36-38]: volatile oils, flavonoids (afzelin, hyperoside, quercitrin), polysaccharides and alkaloids inhibit MAPK signalling, suppress TNF-α and IL-1β and activate AMPK, reducing inflammation and oxidative stress; polysaccharides contribute immune-modulating and antibacterial effects [36-38].

Mentha Arvensis Extract [39-41]: luteolin, rosmarinic acid, oleanolic acid and ursolic acid inhibit pro-inflammatory cytokines and scavenge free radicals in vitro and in silico, with antibacterial activity against Klebsiella pneumoniae and Staphylococcus aureus [40]. [39] is a genus-level review covering Mentha broadly and [41] studied this species together with Aegle marmelos.

Borneolum Syntheticum [42-49]: the ingredient here is synthetic borneol, and only [42] separates synthetic from natural borneol — it found both antipyretic and anti-inflammatory in endotoxic fever rats but with differing chemical and metabolomic profiles. Borneol suppresses TNF-α, IL-1β and IL-6, inhibits NF-κB and MAPK signalling, and increases superoxide dismutase while reducing malondialdehyde [43,46]; it shows analgesic and anti-inflammatory effects in acne [45] and modulates neutrophil chemotaxis and calcium influx [48]. [44] used natural borneol essential oil from Cinnamomum camphora, [47] and [48] used the L- and (-)- natural isomers, and [49] tested a hydrogel.

Radix Scutellariae [50-55]: baicalin, baicalein, wogonin and wogonoside suppress IL-1β, IL-6 and TNF-α, inhibit NF-κB, MAPK and JAK-STAT signalling and activate Nrf2 and PPAR pathways [50-52]. Baicalin accelerated healing in a mouse pressure-ulcer model [53], and topically administered Scutellaria Radix showed efficacy in oral ulcer with active compounds identified [54].

Calamine [56-58]: no study of calamine (zinc carbonate) itself is cited here; the three references below concern zinc ions, zinc sulfate and zinc nutritional status, and are presented as evidence for the zinc component through which calamine is understood to act. Topical zinc sulfate inhibits release of IL-1 and IL-6 from keratinocytes, with reported use in chronic eczema, eczematous psoriasis and lichen planus [57] — the finding closest to this product’s intended use. Zinc inhibits IRF3 phosphorylation and upregulates A20 to suppress NF-κB in macrophages, while zinc deficiency activates the NLRP3 inflammasome, indicating a dose-dependent bidirectional role [56]; zinc and zinc-finger proteins also maintain stratum corneum formation and epidermal barrier integrity, with deficiency associated with loss of Langerhans cells and Th2-skewed cytokine responses [58].

Boswellia sacra [59-66]: [59] and [60] studied Boswellia sacra resin extract showed antimicrobial and antioxidant activity and was formulated into a topical cream [59], and its anti-inflammatory activity was compared against seven related Boswellia and Commiphora species [60]. Boswellic acids inhibit TNF-α, IL-1β and IL-6 and the NF-κB and 5-lipoxygenase pathways [61,62], and extract promoted healing in rat oral ulcers [63].

Commiphora myrrha [67-71]: sesquiterpenes, triterpenes and volatile oils from the resin inhibit nitric oxide, TNF-α and IL-1β, modulate macrophage polarisation and promote fibroblast proliferation and migration [67,70]. Extracts show antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida, together with radical-scavenging activity [67,68]. Myrrh metabolites in inflammation and wound healing are reviewed in [69], and leukocyte proliferation during healing was examined in [71].

Gypsum Fibrosum [72,73]: (raw gypsum) — raw gypsum, but not calcined gypsum, produced an antipyretic effect in LPS-induced fever in rats, attributable to its mineral elements and mediated by reduced hypothalamic COX-2 expression together with gut microbiota changes confirmed by faecal microbiota transplantation [72]; that model is oral and systemic, and does not address topical use. The finding relevant to a cream is non-immunological: Gypsum Fibrosum upregulates aquaporin-3 in keratinocytes via increased intracellular calcium, PKC activation and ERK/CREB phosphorylation, supporting cutaneous water retention [73].

Gypsum Ustum [74]: (calcined gypsum) — comparative study of gypsum phases found that calcined gypsum, particularly the anhydrite III phase, shows better antibacterial and anti-inflammatory activity and better tissue repair than raw gypsum, with pore structure and phase composition determining bioactivity [74].

Zinc [75-84]: zinc is a cofactor for enzymes involved in cell proliferation, immune modulation and extracellular matrix remodelling, supporting keratinocyte migration, collagen synthesis and angiogenesis, and conferring cytoprotection through metallothioneins; deficiency impairs all phases of repair [75,76].

References

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