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Functions

Tangs Derma-zema is a botanical compound formulated to assist the body in expelling and eliminating of feng, it also helps to facilitate detoxification process, thus enhancing the immune system.

Indications

Atopic dermatitis, Eczema, Urticaria (hives), neurodermatitis (Lichen Simplex Chronicus), Seborrheic dermatitis, chronic prurigo (prurigo simplex), hypersensitive/allergic skin disease

Contraindications

Corticosteroids or immunosuppressive drugs. (Herbal and Conventional)

Estimated Recovery Period
治愈时间

  • For patients who have not been placed on immunosuppressant therapy: Approximately 120 days.
  • Immunosuppressants User: For every month that the patient has been on immunosuppressants medications (PO, IM, IV), the time needed for recovery will be lengthened by seven times the usual healing period of 120 days, plus another 120 days. This is just a guideline, and the accuracy of the above assumption is determined by individual physiology as well as the accuracy of information and dosage information provided by the sufferer. Generally, the time to recovery is much longer and more unpredictable for patients with a history of immunosuppressant use. This is because the results are greatly influenced by the dosage and strength of the topical corticosteroid/phototherapy that was prescribed.
  • 没有用过免疫抑制剂者:  约120天.
  • 有用过免疫抑制剂者:  以前口服免疫抑制剂治疗1个月,在120天基础上增加7个月,以此类推。光照疗法和类固醇(激素)药膏的种类及其效能不同,难以计算。

Prognosis of the Immunosuppressants Withdraw Syndrome:
波浪式反复 (免疫抑制剂反弹症)


During Tangs Derma-Zema therapy, all immunosuppressants therapy is stopped. Patients with a history of immunosuppressant use will likely start to experience the so-called Wavelike Flare-up Cycle (See Fig). This is known as the Immunosuppressant Withdrawal Syndrome. Symptoms of eczema which had previously been suppressed by immunotherapy will start to resurface with vigor after the immune system is no longer being curtailed. Over time, as Tangs Derma-Zema gradually takes effect in correcting the immune system’s function, the flareups will subside in frequency and intensity in a wavelike pattern (See Fig). The time to reach the endpoint where the wave draws to a null, will depend on the dosage and potency of the immunosuppressants that the user had formerly consumed.

Diagram of the Recovery Processs
治疗过程图解

Case_15_leg

finger eczema 3

Dosage

3000mg to be taken two times daily

Precaution

  • During the course of Tangs Derma-Zema therapy, abstain from all immunosuppressants and oral contraceptive pills. Abstain from alcohol consumption and avoid late nights. Avoid hot baths, and do not aggravate the skin by scratching or peeling the eczema lesions. A more relaxed lifestyle is recommended.
  • 皮质类固醇等免疫抑制剂药物 (包括UVB和PUVA) 和植物类免疫抑制剂药物 (甘草,白鲜皮,蝉蜕,大黄,金银花,雷公藤等),口服避孕药,饮酒,熬夜,刺激癣疹(搔抓搓),精神情绪不稳定,热水洗浴.

Ingredients

Tangs Derma-zema (Derma-1), each 360mg extract equivalent to 2344mg raw herbs:
Radix Saposhnikoviae Divaricatae [1-5] 313mg
Radix Paeoniae Alba [6,7] 480mg
Radix Astragali [8-12] 588mg
Ramulus Cinnamomi [13,14] 300mg
Semen Coicis [15] 600mg
Radix Codonopsis Pilosula [16-18] 63mg

Tangs Derma-2, each 360mg extract equivalent to 800mg raw herbs:
Radix Ophiopogon Japonicus [19-23] 100mg
Radix Salviae Miltiorrhizae [24-27] 100mg
Radix Scrophulariae  [28,29] 270mg
Rhizoma Atractylodis Macrocephalae [30-34] 330mg

Tangs Derma-3, each 360mg extract equivalent to 1150mg raw herbs:
Radix Salviae Miltiorrhizae [24-27] 200mg
Radix Scrophulariae [28,29] 270
Rhizoma Atractylodis Macrocephalae [30-32] 230mg
Radix Asparagus Cochinchinensis [33-35] 100mg
Fructus Lycii [36-39] 350mg

Tangs Derma-4, each 360mg extract equivalent to 2310mg raw herbs:
Radix Salviae Miltiorrhizae [24-27] 200mg
Radix Scrophulariae [28,29] 270
Rhizoma Atractylodis Macrocephalae [30-32] 330mg
Fructus Lycii [36-39] 350mg
Folium Mori [40-42] 280mg
Flos Chrysanthemi [43-47] 300mg

Tangs Derma-5, each 360mg extract equivalent to 940mg raw herbs:
Radix Saposhnikoviae Divaricatae [1-5] 500mg
Radix Astragali [8-12] 150mg
Rhizoma Atractylodis Macrocephalae [30-32] 150mg
Rhizoma Zingiberis Recens [48-51] 100mg
Fructus Zizyphi Jujubae  [52-55] 40mg

Clinical Evidence

Radix Saposhnikoviae Divaricatae [1-5] exhibits immunomodulatory effects primarily through its polysaccharide components, which influence both innate and adaptive immune responses. The most robust evidence demonstrates that it extract can suppress Th1 differentiation and function, as shown by reduced IFN-γ production and T-bet expression, and a decreased Th1/Th2 cytokine ratio in murine models of allergic contact dermatitis. This effect is mediated in part by downregulation of dendritic cell maturation and costimulatory molecule expression, thereby limiting Th1 polarization and inflammatory infiltration.

Radix Paeoniae Alba [6,7] has been shown to suppress Th2 cell-mediated immune responses, as evidenced by reduced serum IgE, decreased IL-4/IFN-γ ratios, and reversal of Th2 skewing. This suggests a downregulation of Th2 activity, which is central to allergic inflammation. There is indirect evidence that this suppression may also rebalance Th1/Th2 responses, as Th1 cytokines (e.g., IFN-γ) are relatively increased when Th2 is suppressed. It also inhibits mast cell activation, which may indirectly modulate T cell responses by reducing antigen presentation and inflammatory cytokine milieu.

Radix Astragali [8-12] modulates the balance between Th1, Th2, Th17, and regulatory T cells (Treg). Specifically, its flavonoids suppress Th1 and Th17 differentiation and cytokine production (e.g., IFN-γ, IL-17), while promoting Treg differentiation and function, primarily via JAK/STAT and NF-κB signaling pathways. This mechanism is relevant in autoimmune and inflammatory disease models, where shifting the Th17/Treg axis reduces pathogenic inflammation. It also influences Th2 responses, with evidence showing increased IL-4 production and reduced IFN-γ, indicating a shift toward Th2 polarization in murine models. This may be beneficial in allergic conditions, but the overall effect is context-dependent. For CD8+ T cells, Radix Astragali extracts increase the expression of CD8 and related transcription factors, supporting cytotoxic T cell activation and proliferation.

Ramulus Cinnamomi [13,14] promotes Th1 cell recovery and suppresses Th17 and regulatory T cell (Treg) expansion following immune injury, such as low-dose total body irradiation. Mechanistically, it enhances T-bet expression (Th1 master transcription factor), increases IFN-γ production, and limits Foxp3 transcription (Treg marker), thereby shifting the balance toward Th1-mediated antitumor immunity and away from immunosuppressive Treg and pro-inflammatory Th17 responses. In models of autoimmune disease (experimental allergic encephalomyelitis), Ramulus Cinnamomi upregulates Treg populations, likely via reduction of nitric oxide production, which is associated with amelioration of disease severity. The protective effect is abrogated when Tregs are neutralized, indicating a direct role for Ramulus Cinnamomi in Treg maintenance in this context. These findings suggest context-dependent effects: it can both suppress and promote Treg populations depending on the underlying immune milieu.

Semen Coicis [15] regulate the differentiation and proliferation of Th17 cells, as evidenced by reduced IL-17 production. This is mediated by suppression of the JAK-STAT signaling pathway, which is central to Th17 cell development and effector function. Treatment with Semen Coicis extract leads to reduced IFN-γ production and Th1 cell effector function, reduces FoxP3 expression in induced Treg cells.

Radix Codonopsis pilosula [16-18], primarily through its polysaccharide components, exerts immunomodulatory effects on multiple T cell subsets. In murine models of immunosuppression, administration of Codonopsis pilosula polysaccharides (RCP) helps maintain the homeostasis of CD4+ T cells, CD8+ T cells, Th1 cells, Th2 cells, regulatory T cells (Tregs), and Th17 cells. Specifically, RCP preserves the balance between Th1/Th2 and Treg/Th17 populations, which is critical for immune regulation and prevention of immune dysregulation. RCP also stabilizes the CD4/CD8 ratio and modulates cytokine profiles, including TNF-α, IL-1β, and IL-10, supporting both pro- and anti-inflammatory responses. Codonopsis pilosula oligosaccharides and inulin-type fructans further enhance immune function by promoting lymphocyte proliferation, increasing cytokine production (notably IL-2 and IFN-γ, which are associated with Th1 responses), and activating MAPK and NF-κB signaling pathways, which are central to T cell activation and differentiation. These effects suggest a broad enhancement of T cell-mediated immunity, including cytotoxic CD8+ T cell function.

Radix Ophiopogon Japonicus [19-23] polysaccharides and liposomal formulations have been shown to enhance splenocyte proliferation and increase the proportion of CD4+ and CD8+ T cells in vivo, as well as modulate cytokine production. It ameliorate eczema-like lesions in murine models by suppressing skin thickening, mast cell activation, and pro-inflammatory cytokine expression. Mechanistically, ophiopogonin D inhibits p38 and ERK activation and reduces NF-κB nuclear translocation in inflamed human keratinocytes, leading to decreased expression of inflammatory mediators.

Radix Salviae Miltiorrhizae [24-27] bioactive compounds tanshinones I and IIA suppress Th1 differentiation and function, primarily by inhibiting STAT3/STAT5 phosphorylation, leading to reduced IFN-γ production and Th1-mediated inflammation. Salvianolic acid A and tanshinone IIA decrease Th2 cytokines (IL-4, IL-13) in allergic asthma models, indicating inhibition of Th2 responses and potential anti-allergic effects. Tanshinones inhibit Th17 differentiation and function, likely via STAT pathway blockade, which may reduce IL-17-mediated inflammation in autoimmune diseases. Polysaccharides from Salvia miltiorrhiza promote Treg differentiation and function, enhancing immune tolerance and potentially mitigating autoimmunity, and enhance CD8+ T cell cytotoxicity and promote tumor cell apoptosis, supporting anti-tumor immunity.

Radix Scrophulariae  [28,29] polysaccharides activate macrophages via TLR2-dependent MAPK and NF-κB signaling, leading to increased production of NO and TNF-α, which are critical for host defense against pathogens. This macrophage activation may enhance innate immune responses to bacterial and viral infections. The immunomodulatory activity described in the literature is primarily focused on macrophage activation and polarization, with indirect potential to influence adaptive immunity through changes in the inflammatory milieu.

Rhizoma Atractylodis Macrocephalae [30-32] primarily modulates immune responses by activating macrophages and altering cytokine profiles, which can indirectly affect the differentiation and function of multiple T helper cell subsets, especially Th1 and Th17 cells, via NF-κB and JAK-STAT pathways.

Radix Asparagus cochinchinensis [33-35] has demonstrated anti-inflammatory effects in both acute and chronic cutaneous inflammation models. In murine studies, extracts significantly inhibited pro-inflammatory cytokines (TNF-α, IL-1β), suppressed neutrophil myeloperoxidase activity, and improved histopathological markers of dermatitis, suggesting therapeutic potential in immune-mediated skin diseases such as dermatitis. In addition, A. cochinchinensis exhibits photoprotective properties against UVB-induced skin damage in vitro. These effects include enhanced antioxidant enzyme activity (HO-1, SOD, CAT), reduced reactive oxygen species (ROS), and inhibition of matrix metalloproteinase expression—mechanisms relevant to the prevention of photoaging and UV-induced skin injury. Furthermore, extracts have been shown to increase antityrosinase activity and suppress melanin synthesis in human melanocytes, indicating possible applications in managing hyperpigmentation disorders and in cosmetic formulations.

Folium Mori [40-42] have demonstrated anti-inflammatory and immunomodulatory effects in the context of atopic dermatitis, with clinical studies showing improvement in skin lesions and normalization of immune biomarkers such as Granzyme B, but without direct measurement of T cell subset frequencies or function. In vitro and animal studies suggest that Folium Mori extracts can activate macrophages and promote Th1-type immune responses via TLR4 signaling, increasing cytokines such as IFN-γ and TNF-α, which are associated with Th1 polarization.

Flos Chrysanthemi [43-47] have demonstrated antiallergic effects by inhibiting antigen-induced degranulation and scratching behavior in mice, suggesting a potential role in allergic dermatitis and pruritic conditions. Additionally, its antioxidant and anti-glycation activities may contribute to skin barrier protection and anti-aging effects, as supported by in vitro studies showing inhibition of collagenase and glycation processes relevant to skin integrity. Its rich content of flavonoids, phenolic acids, and polysaccharides have been shown in vitro and in animal models to suppress pro-inflammatory cytokines (e.g., IL-1β, IL-6, IL-8), inhibit oxidative stress, and modulate immune cell activity, including macrophage and mast cell responses.

Rhizoma Zingiberis Recens [48-51] have been shown to restore Th1/Th2 balance in immunocompromised mice, normalizing both Th1 (IFN-γ) and Th2 cytokine responses and enhancing antigen-specific antibody production after influenza vaccination. This suggests a rebalancing effect on Th1 and Th2 cells, rather than simple suppression or activation of one subset over the other. In vitro, gingerols increase IFN-γ (Th1) secretion in activated human T lymphocytes, further supporting a Th1-promoting effect.

Fructus Zizyphi Jujubae [52-55  polysaccharides broadly enhance T cell-mediated immunity, lymphocyte proliferation, increase splenic and thymic indices, and modulate cytokine production, with evidence for upregulation of Th1, Th2, Th17, and Treg-associated cytokines, and a shift in CD4+/CD8+ ratios.

Reference

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