logo

Functions

Tangs Psoria is a botanical compound formulated to stimulate the Yang component of the human body thereby promoting the blood circulation and facilitate detoxification process. Tangs Psoria enhance and normalize the body immune system

Indications

Psoriasis (Plaque Psoriasis, Guttate Psoriasis, Inverse Psoriasis, Pustular Psoriasis), Eczema (Atopic Dermatitis), Palmoplantar Pustulosis (PPS), Acrodermatitis continua (Hallopeau disease)
Erythrodermic Psoriasis patients must consult doctor before starting treatment

Contraindications

Corticosteroids or immunosuppressive drugs. (Herbal and Conventional)

Estimated Recovery Peroid 治愈时间

  • For patients who have not been placed on immunosuppressant therapy: Approximately 120 days.
  • Immunosuppressants User: For every month that the patient has been on immunosuppressants medications (PO, IM, IV), the time needed for recovery will be lengthened by seven times the usual healing period of 120 days, plus another 120 days. This is just a guideline, and the accuracy of the above assumption is determined by individual physiology as well as the accuracy of information and dosage information provided by the sufferer. Generally, the time to recovery is much longer and more unpredictable for patients with a history of immunosuppressant use. This is because the results are greatly influenced by the dosage and strength of the topical corticosteroid/phototherapy that was prescribed.
  • 没有用过免疫抑制剂者:  约120天.
  • 有用过免疫抑制剂者:  以前口服免疫抑制剂治疗1个月,在120天基础上增加7个月,以此类推。
    光照疗法和类固醇(激素)药膏的种类及其效能不同,难以计算。

Prognosis of the Immunosuppressants Withdraw Syndrome:
波浪式反复(免疫抑制剂反弹症)

During Tangs Psoria herbal therapy, all immunosuppressants therapy is stopped. Patients with a history of immunosuppressant use will likely start to experience the so-called Wavelike Flare-up Cycle (above figure). This is known as the Immunosuppressant Withdrawal Syndrome. Symptoms of psoriasis which had previously been suppressed by immunotherapy will start to resurface with vigor after the immune system is no longer being curtailed. Over time, as Tangs Psoria gradually takes effect in correcting the immune system’s function, the flareups will subside in frequency and intensity in a wavelike pattern (above figure). The time to reach the endpoint where the wave draws to a null, will depend on the dosage and potency of the immunosuppressants that the user had formerly consumed.

Description of Criterion for the Curative Progress
治愈标准

  • After a patient has benefited from Tangs Psoria treatment, all typical skin lesions and flareups will have subsided. Subsequently, some of the formerly psoriatic areas should take on a light tone, similar in color to vitiligo (See Panel.D). This is a normal sign, and it will take another 3 months (the time needed for skin cells to be renewed) for normal healthy skin color to return to the affected areas. Thereafter, no further TANGS medication is will be required. The likelihood of relapse will be very low, possibly for the next 30 years. (The first patient ever treated and cured with TANGS treatment in 1980, has not experienced a relapse to this day – a 30-year period.)
  • 所有的癣疹完全消退并且其中一些消退的癣疹原地出现白癜风样颜色 Panel.D (大约3个月左右变为正常肤色),治愈后约30年不复发(第一例患者于1980年痊愈,至今未复发)。

Diagram of the Recovery Processs
治疗过程图解

 


Dosage

3000mg to be taken two times daily

Precaution

  • During the course of Tangs Psoria therapy, abstain from all immunosuppressants and oral contraceptive pills. Abstain from alcohol consumption and avoid late nights. Avoid hot baths, and do not aggravate the skin by scratching or peeling the psoriatic lesions. A more relaxed lifestyle is recommended.
  • 皮质类固醇等免疫抑制剂药物 (包括UVB和PUVA) 和植物类免疫抑制剂药物 (甘草,白鲜皮,蝉蜕,大黄,金银花,雷公藤等),口服避孕药,饮酒,熬夜,刺激癣疹(搔抓搓),精神情绪不稳定,热水洗浴.

Ingredients

Tangs Psoria, each 360mg extract equivalent to 2354mg raw herbs:
Rhizoma Zingiberis [1-4] 429mg
Radix Paeoniae Alba [5,6] 156mg
Radix Astragali [7-11] 313mg
Radix Salviae Miltiorrhizae [12-15] 556mg
Ramulus Cinnamomi [16,17] 299mg
Semen Coicis [18] 538mg
Radix Codonopsis Pilosula [19-21] 63mg

Tangs Psoria-2, each 360mg extract equivalent to 1500mg raw herbs:
Radix Rehmannia glutinosa [22-26] 400mg
Radix Scrophulariae [27,28] 400mg
Radix Codonopsis Pilosula [29-32] 80mg
Fructus Lycii [33-36] 120mg
Flos Chrysanthemi [37-41] 500mg

Tangs Psoria-3, each 360mg extract equivalent to 2030mg raw herbs:
Radix Rehmannia glutinosa [22-26] 420mg
Radix Scrophulariae [27,28] 420mg
Radix Codonopsis Pilosula [29-32] 80mg
Flos Chrysanthemi [37-41] 380mg
Folium Mori [42-44] 380mg
Fructus Lycii [33-36] 350mg

Tangs Psoria-4, each 360mg extract equivalent to 2263mg raw herbs:
Radix Astragali [7-11] 313mg
Radix Rehmannia glutinosa [22-26] 420mg
Radix Scrophulariae [27,28] 420mg
Flos Chrysanthemi [37-41] 380mg
Folium Mori [42-44] 380mg
Fructus Lycii [33-36] 350mg

Tangs Psoria-5, each 360mg extract equivalent to 2263mg raw herbs:
Radix Rehmannia glutinosa [45-55] 333mg
Radix Adenophora tetraphylla [56-58] 333mg
Fructus Ligustri Lucidi [59-62] 600mg
Fructus Lycii [33-36] 600mg
Flos Chrysanthemi [37-41] 333mg
Fructus Gardenia jasminoide [63-66]100mg
Fructus Mori [42-44] 100mg

Clinical Evidence

Rhizoma Zingiberis [1-4] have been shown to restore Th1/Th2 balance in immunocompromised mice, normalizing both Th1 (IFN-γ) and Th2 cytokine responses and enhancing antigen-specific antibody production after influenza vaccination. This suggests a rebalancing effect on Th1 and Th2 cells, rather than simple suppression or activation of one subset over the other. In vitro, gingerols increase IFN-γ (Th1) secretion in activated human T lymphocytes, further supporting a Th1-promoting effect.

Radix Paeoniae Alba [5,6] has been shown to suppress Th2 cell-mediated immune responses, as evidenced by reduced serum IgE, decreased IL-4/IFN-γ ratios, and reversal of Th2 skewing. This suggests a downregulation of Th2 activity, which is central to allergic inflammation. There is indirect evidence that this suppression may also rebalance Th1/Th2 responses, as Th1 cytokines (e.g., IFN-γ) are relatively increased when Th2 is suppressed. It also inhibits mast cell activation, which may indirectly modulate T cell responses by reducing antigen presentation and inflammatory cytokine milieu.

Radix Astragali [7-11] modulates the balance between Th1, Th2, Th17, and regulatory T cells (Treg). Specifically, its flavonoids suppress Th1 and Th17 differentiation and cytokine production (e.g., IFN-γ, IL-17), while promoting Treg differentiation and function, primarily via JAK/STAT and NF-κB signaling pathways. This mechanism is relevant in autoimmune and inflammatory disease models, where shifting the Th17/Treg axis reduces pathogenic inflammation. It also influences Th2 responses, with evidence showing increased IL-4 production and reduced IFN-γ, indicating a shift toward Th2 polarization in murine models. This may be beneficial in allergic conditions, but the overall effect is context-dependent. For CD8+ T cells, Radix Astragali extracts increase the expression of CD8 and related transcription factors, supporting cytotoxic T cell activation and proliferation.

Radix Salviae Miltiorrhizae [12-15] bioactive compounds tanshinones I and IIA suppress Th1 differentiation and function, primarily by inhibiting STAT3/STAT5 phosphorylation, leading to reduced IFN-γ production and Th1-mediated inflammation. Salvianolic acid A and tanshinone IIA decrease Th2 cytokines (IL-4, IL-13) in allergic asthma models, indicating inhibition of Th2 responses and potential anti-allergic effects. Tanshinones inhibit Th17 differentiation and function, likely via STAT pathway blockade, which may reduce IL-17-mediated inflammation in autoimmune diseases. Polysaccharides from Salvia miltiorrhiza promote Treg differentiation and function, enhancing immune tolerance and potentially mitigating autoimmunity, and enhance CD8+ T cell cytotoxicity and promote tumor cell apoptosis, supporting anti-tumor immunity.

Ramulus Cinnamomi [16,17] promotes Th1 cell recovery and suppresses Th17 and regulatory T cell (Treg) expansion following immune injury, such as low-dose total body irradiation. Mechanistically, it enhances T-bet expression (Th1 master transcription factor), increases IFN-γ production, and limits Foxp3 transcription (Treg marker), thereby shifting the balance toward Th1-mediated antitumor immunity and away from immunosuppressive Treg and pro-inflammatory Th17 responses. In models of autoimmune disease (experimental allergic encephalomyelitis), Ramulus Cinnamomi upregulates Treg populations, likely via reduction of nitric oxide production, which is associated with amelioration of disease severity. The protective effect is abrogated when Tregs are neutralized, indicating a direct role for Ramulus Cinnamomi in Treg maintenance in this context. These findings suggest context-dependent effects: it can both suppress and promote Treg populations depending on the underlying immune milieu.

Semen Coicis [18] regulate the differentiation and proliferation of Th17 cells, as evidenced by reduced IL-17 production. This is mediated by suppression of the JAK-STAT signaling pathway, which is central to Th17 cell development and effector function. Treatment with Semen Coicis extract leads to reduced IFN-γ production and Th1 cell effector function, reduces FoxP3 expression in induced Treg cells.

Radix Codonopsis pilosula [19-21], primarily through its polysaccharide components, exerts immunomodulatory effects on multiple T cell subsets. In murine models of immunosuppression, administration of Codonopsis pilosula polysaccharides (RCP) helps maintain the homeostasis of CD4+ T cells, CD8+ T cells, Th1 cells, Th2 cells, regulatory T cells (Tregs), and Th17 cells. Specifically, RCP preserves the balance between Th1/Th2 and Treg/Th17 populations, which is critical for immune regulation and prevention of immune dysregulation. RCP also stabilizes the CD4/CD8 ratio and modulates cytokine profiles, including TNF-α, IL-1β, and IL-10, supporting both pro- and anti-inflammatory responses. Codonopsis pilosula oligosaccharides and inulin-type fructans further enhance immune function by promoting lymphocyte proliferation, increasing cytokine production (notably IL-2 and IFN-γ, which are associated with Th1 responses), and activating MAPK and NF-κB signaling pathways, which are central to T cell activation and differentiation. These effects suggest a broad enhancement of T cell-mediated immunity, including cytotoxic CD8+ T cell function.

Radix Rehmannia glutinosa [22-26] polysaccharide and glycoside components have been shown to enhance general T lymphocyte proliferation and function, with increased production of cytokines such as IL-2 and IFN-γ, which are associated with Th1 responses. This suggests a potential for promoting Th1 differentiation and activity. There is also evidence of increased IL-10 production, which may support Treg function and anti-inflammatory effects. Enhancement of dendritic cell activation by rehamannis polysaccharides may indirectly promote T cell activation and differentiation.

Radix Scrophulariae [27,28] Polysaccharides activate macrophages via TLR2-dependent MAPK and NF-κB signaling, leading to increased production of NO and TNF-α, which are critical for host defense against pathogens. This macrophage activation may enhance innate immune responses to bacterial and viral infections. The immunomodulatory activity described in the literature is primarily focused on macrophage activation and polarization, with indirect potential to influence adaptive immunity through changes in the inflammatory milieu.

Radix Codonopsis Pilosula [29-32] polysaccharides have been shown to synergize with antioxidant polyphenols in microneedle-based drug delivery systems, resulting in significant attenuation of inflammation and oxidative stress in a murine model of imiquimod-induced psoriasis. This effect is mediated by inhibition of the IL-23/IL-17 axis, a key pathway in psoriasis pathogenesis, and by scavenging reactive oxygen species (ROS) at sites of skin inflammation, thereby improving local drug penetration and reducing disease severity. Additionally, polyacetylenol glycosides with potent anti-inflammatory activity, demonstrated by their ability to inhibit nitric oxide production and decrease TNF-α and IL-6 levels in vitro, suggesting a mechanistic basis for potential benefit in inflammatory skin conditions. The polysaccharides and oligosaccharides from Codonopsis pilosula also enhance immune function and modulate cytokine production, which may contribute to their therapeutic effects in immune-mediated skin diseases.

Fructus Lycii [33-36] flavonoids, such as quercetin, can inhibit production of TNF-α, MCP-1, and IL-1β, and downregulate ICAM-1 and VCAM-1 expression in vitro studies using LPS-stimulated endothelial cells, suggesting potential to reduce leukocyte recruitment and inflammation in the skin. It also exhibit antioxidant activity, which may protect against oxidative stress-induced skin damage, a common feature in chronic inflammatory skin diseases. Emerging mechanistic insights indicate that Fructus Lycii may modulate the gut-skin axis by altering gut microbiota composition, which can indirectly influence systemic and cutaneous immune responses, including T cell subset balance.

Flos Chrysanthemi [37-41] have demonstrated antiallergic effects by inhibiting antigen-induced degranulation and scratching behavior in mice, suggesting a potential role in allergic dermatitis and pruritic conditions. Additionally, its antioxidant and anti-glycation activities may contribute to skin barrier protection and anti-aging effects, as supported by in vitro studies showing inhibition of collagenase and glycation processes relevant to skin integrity. Its rich content of flavonoids, phenolic acids, and polysaccharides have been shown in vitro and in animal models to suppress pro-inflammatory cytokines (e.g., IL-1β, IL-6, IL-8), inhibit oxidative stress, and modulate immune cell activity, including macrophage and mast cell responses.

Folium Mori [42-44] have demonstrated anti-inflammatory and immunomodulatory effects in the context of atopic dermatitis, with clinical studies showing improvement in skin lesions and normalization of immune biomarkers such as Granzyme B, but without direct measurement of T cell subset frequencies or function. In vitro and animal studies suggest that Folium Mori extracts can activate macrophages and promote Th1-type immune responses via TLR4 signaling, increasing cytokines such as IFN-γ and TNF-α, which are associated with Th1 polarization.

Radix Rehmannia glutinosa [45-55] has been shown to enhance Th1 immune responses, as indicated by increased IFN-γ and IL-2 production in murine T lymphocytes, thereby promoting Th1 differentiation and strengthening cellular immunity. Beyond Th1 activity, it also stimulates general lymphocyte proliferation, potentially involving Th2 subsets, and supports broad T cell activation, including CD8⁺ cytotoxic T cells. Some studies further report elevated IL-10 production, suggesting an additional anti-inflammatory or regulatory effect. Collectively, these findings highlight the immunomodulatory and anti-inflammatory properties of R. glutinosa, particularly relevant to skin diseases such as atopic dermatitis and psoriasis. In atopic dermatitis models, topical R. glutinosa extract suppresses Th2-mediated inflammation by reducing IL-4 expression, serum IgE, and histamine, while downregulating chemokines and adhesion molecules involved in leukocyte recruitment. This shift away from Th2 dominance addresses a central mechanism of atopic dermatitis pathogenesis. In psoriasis, both network pharmacology and experimental studies demonstrate that active compounds such as aucubin downregulate pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and inhibit p38MAPK signaling, a pathway implicated in Th1, Th17, and Th22 cell activation. Because these subsets drive keratinocyte hyperproliferation and chronic inflammation, modulation of these pathways by R. glutinosa may attenuate Th1/Th17/Th22-driven psoriatic inflammation. Furthermore, polysaccharides derived from R. glutinosa have been shown to enhance lymphocyte proliferation and upregulate IL-2 and IFN-γ, reinforcing Th1 responses, while also increasing IL-4 and IL-10, which promote Th2 and regulatory T cell (Treg) activity. Such broad immunomodulation may help restore immune homeostasis in chronic inflammatory skin conditions.

Radix Adenophora tetraphylla [56-58] has demonstrated notable anti-inflammatory and immunomodulatory effects in preclinical models of skin disease, particularly atopic dermatitis. In murine models, root extracts alleviated atopic-like skin lesions, reduced mast cell infiltration, decreased epidermal thickness, and lowered IL-4 and IgE levels—collectively indicating suppression of Th2-mediated inflammation and improvement of skin barrier function. The extract also activated antioxidant pathways, including Nrf2/HO-1, further supporting its therapeutic potential in atopic dermatitis. Moreover, studies on related Adenophora species report attenuation of both Th1- and Th2-associated cytokine production, and in some cases potential regulatory effects on Th17 cells as well.

Fructus Ligustri Lucidi [59-62] extract exerts immunomodulatory and anti-inflammatory effects on several key immune and inflammatory markers. It downregulates pro-inflammatory cytokines such as interleukin-17 (IL-17), tumor necrosis factor (TNF), and interleukin-1β (IL-1β), as demonstrated in murine colitis and diabetic nephropathy models, where oral administration led to reduced tissue inflammation and improved epithelial integrity. Network pharmacology and molecular docking studies further confirm that LLF targets the IL-17 and TNF signaling pathways, suppressing their activity and thereby attenuating chronic inflammatory responses. It promotes anti-inflammatory cytokines such as interleukin-4 (IL-4), and enhances lymphocyte subsets (CD3, CD4/CD8), supporting a shift toward Th2-mediated immune responses. Hydroxytyrosol, a major active compound, significantly increases IL-4 and TNF-α secretion, and upregulates IFN-γ, indicating broad immunoregulatory activity.

Fructus Gardenia jasminoide [63-66] improved skin barrier function, reduced dermatitis scores, and decreased scratching behavior. Mechanistically, these effects are associated with suppression of Th2-mediated immune responses, as evidenced by reduced levels of Th2 cytokines (IL-4, IL-5, IL-13), serum IgE, and chemokines, as well as decreased mast cell infiltration and pro-inflammatory cytokines in the skin. The geniposide, a major active component, has been shown in non-dermatologic models to downregulate Th17 cytokines and upregulate Treg-associated cytokines, suggesting potential broader immunoregulatory effects.

Reference

  1. Dried Ginger Extract Restores the T Helper Type 1/­T Helper Type 2 Balance and Antibody Production in Cyclophosphamide-Induced Immunocompromised Mice After Flu Vaccination. Kim J, Lee H, You S.Nutrients. 2022;14(9):1984. doi:10.3390/nu14091984.
  2. Quantitation of Gingerols in Human Plasma by Newly Developed Stable Isotope Dilution Assays and Assessment of Their Immunomodulatory Potential. Schoenknecht C, Andersen G, Schmidts I, Schieberle P. Journal of Agricultural and Food Chemistry. 2016;64(11):2269-79.
  3. The “Root” Causes Behind the Anti-Inflammatory Actions of Ginger Compounds in Immune Cells.Pázmándi K, Szöllősi AG, Fekete T. Frontiers in Immunology. 2024;15:1400956. doi:10.3389/fimmu.2024.1400956.
  4. Ginger-Derived Bioactive Compounds Attenuate the Toll-Like Receptor Mediated Responses of Human Dendritic Cells. Pázmándi K, Ágics B, Szöllősi AG, Bácsi A, Fekete T. European Journal of Pharmacology. 2024;967:176399.
  5. Protective Effect of Paeoniae Radix Alba Root Extract on Immune Alterations in Mice With Atopic Dermatitis.  Jo GH, Kim SN, Kim MJ, Heo Y. Journal of Toxicology and Environmental Health. Part A. 2018;81(12):502-511.
  6. The Inhibition of Mast Cell Activation of Radix Paeoniae Alba Extraction Identified by TCRP Based and Conventional Cell Function Assay Systems. Fu H, Cheng H, Cao G, et al. PloS One. 2016;11(5):e0155930.
  7. Total Flavonoids of Astragalus Inhibit Activated CD4[Formula: See Text] T Cells and Regulate Differentiation of Th17/­Th1/­Treg Cells in Experimental Autoimmune Encephalomyelitis Mice by JAK/­STAT and NF[Formula: See Text]B Signaling Pathways. Han XY, Xu N, Yuan JF, et al. The American Journal of Chinese Medicine. 2023;51(5):1233-1248. Anti-Inflammatory and Immunostimulatory Activities of Astragalosides. Qi Y, Gao F, Hou L, Wan C. The American Journal of Chinese Medicine. 2017;45(6):1157-1167.
  8. The Role of Th17/­Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review.Xu YY, Wang DM, Liang HS, et al. The American Journal of Chinese Medicine. 2020;48(3):535-558.
  9. Immunomodulatory Effect of Astragali Radix Extract on Murine TH1/­TH2 Cell Lineage Development. Kang H, Ahn KS, Cho C, Bae HS. Biological & Pharmaceutical Bulletin. 2004;27(12):1946-50.
  10. Astragalus Extract Mixture HT042 Reverses Cyclophosphamide-Induced Immunosuppression Through Dual Modulation of Innate and Adaptive Immunity. Kim SY, Son J, Kim M, et al. International Journal of Molecular Sciences. 2025;26(10):4850.
  11. Tanshinone I Inhibits the Functions of T Lymphocytes and Exerts Therapeutic Effects on Delayed-Type Hypersensitivity Reaction via Blocking STATs Signaling Pathways. Lu Z, Liao H, Zhang M, et al. European Journal of Pharmacology. 2024;985:177128.
  12. Research Progress on Regulation of Immune Response by Tanshinones and Salvianolic Acids of Danshen (Salvia Miltiorrhiza Bunge). Tang J, Zhao X. Molecules (Basel, Switzerland). 2024;29(6):1201. doi:10.3390/molecules29061201.
  13. Anti-Allergic Effects of Salvianolic Acid a and Tanshinone IIA From Salvia Miltiorrhiza Determined Using in Vivo and in Vitro Experiments. Heo JY, Im DS. International Immunopharmacology. 2019;67:69-77. doi:10.1016/j.intimp.2018.12.010.
  14. Structural Analysis of Salvia Miltiorrhiza Polysaccharide and Its Regulatory Functions on T Cells Subsets in Tumor-Bearing Mice Combined With Thymopentin. Ji H, Fan Y, Long Y, et al. International Journal of Biological Macromolecules. 2024;277(Pt 1):133832. doi:10.1016/j.ijbiomac.2024.133832.
  15. Salvia Miltiorrhiza Polysaccharide Activates T Lymphocytes of Cancer Patients Through Activation of TLRs Mediated -MAPK and -NF-κB Signaling Pathways. Chen Y, Li H, Li M, et al. Journal of Ethnopharmacology. 2017;200:165-173. doi:10.1016/j.jep.2017.02.029.
  16. Recovery Profiles of T-Cell Subsets Following Low-Dose Total Body Irradiation and Improvement With Cinnamon. Zheng X, Guo Y, Wang L, et al. International Journal of Radiation Oncology, Biology, Physics. 2015;93(5):1118-26.
  17. Cinnamon Ameliorates Experimental Allergic Encephalomyelitis in Mice via Regulatory T Cells: Implications for Multiple Sclerosis Therapy. Mondal S, Pahan K. PloS One. 2015;10(1):e0116566.
  18. Deciphering the Mechanism of Extract on Th17 Cells Through in-Depth Transcriptomic Profiling and Analysis. Nandan A, Sharma V, Banerjee P, et al. Frontiers in Pharmacology. 2022;13:1056677.
  19. Polysaccharide From Radix Codonopsis Has Beneficial Effects on the Maintenance of T-Cell Balance in Mice. Deng X, Fu Y, Luo S, et al. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2019;112:108682. doi:10.1016/j.biopha.2019.108682.
  20. Specific Inulin in Codonopsis Pilosula Exerts Immunological Enhancement by Promoting Cellular Uptake and Regulating P65-Dependent MAPK and NF-κb Pathways. Gao Z, Ren J, Ke C, et al. Journal of Agricultural and Food Chemistry. 2025;. doi:10.1021/acs.jafc.5c05401.
  21. Immune-Enhancement Effects of Oligosaccharides From Codonopsis Pilosula on Cyclophosphamide Induced Immunosuppression in Mice. Bai RB, Zhang YJ, Fan JM, et al. Food & Function. 2020;11(4):3306-3315. doi:10.1039/c9fo02969a.
  22. Immunoenhancement Effect of Rehmannia Glutinosa Polysaccharide on Lymphocyte Proliferation and Dendritic Cell. Huang Y, Jiang C, Hu Y, et al. Carbohydrate Polymers. 2013;96(2):516-21.
  23. Rehmannia Glutinosa Polysaccharides Alleviate Cyclophosphamide-Induced Immunosuppression by Enhancing Immunity and Restoring Intestinal Homeostasis. Yu L, Shi X, Lu X, et al. International Journal of Biological Macromolecules. 2025;311(Pt 1):143692.
  24. Effects of Polysaccharide From Hot-Compressed Steamed Rehmannia Glutinosa on the Immune System and Gut Microbiota in an Immunosuppressed Mice Model. Jia Y, Zhang Z, Zhang S, et al. International Immunopharmacology. 2024;142(Pt B):113202.
  25. Rehmannia Glutinosa Polysaccharide Promoted Activation of Human Dendritic Cells. Wang Y, Kwak M, Lee PC, Jin JO. International Journal of Biological Macromolecules. 2018;116:232-238.
  26. Rehmannia Glutinosa Polysaccharide Functions as a Mucosal Adjuvant to Induce Dendritic Cell Activation in Mediastinal Lymph Node. Kwak M, Yu K, Lee PC, Jin JO. International Journal of Biological Macromolecules. 2018;120(Pt B):1618-1623.
  27. Molecular Insights Into the Macrophage Immunomodulatory Effects of Scrophulariae Radix Polysaccharides. Zhao M, Zheng S, Wang M, et al. Chemistry & Biodiversity. 2023;20(11):e202301180.
  28. Traditional Chinese Medicine in Regulating Macrophage Polarization in Immune Response of Inflammatory Diseases. Chen S, Zeng J, Li R, et al. Journal of Ethnopharmacology. 2024;325:117838.
  29. Delivery of Penetration-Enhancing Antioxidant Polyphenol Nanoparticles With Codonopsis Pilosula Polysaccharide Microneedles for Synergistic Treatment of Psoriasis. Liu S, Song S, Zhang Y, et al. Carbohydrate Polymers. 2025;363:123777.
  30. UV-guided Separation of Polyacetylenol Glycosides From the Edible Roots of Codonopsis Pilosula and Their Anti-Inflammatory Activity. Jiang X, Wang L, Chen Y, et al. Phytochemistry. 2025;238:114554.
  31. Extraction, Purification, Structural Characteristics and Biological Properties of the Polysaccharides From Codonopsis Pilosula: A Review. Luan F, Ji Y, Peng L, et al. Carbohydrate Polymers. 2021;261:117863.
  32. Immune-Enhancement Effects of Oligosaccharides From Codonopsis Pilosula on Cyclophosphamide Induced Immunosuppression in Mice. Bai RB, Zhang YJ, Fan JM, et al. Food & Function. 2020;11(4):3306-3315. doi:10.1039/c9fo02969a.
  33. Immune Activities of Polysaccharides Isolated From Lycium Barbarum L. What Do We Know So Far?. Xiao Z, Deng Q, Zhou W, Zhang Y. Pharmacology & Therapeutics. 2022;229:107921.
  34. Exploration of Chemical Compositions in Different Germplasm Wolfberry Using UPLC-MS/­MS and Evaluation of the in Vitro Anti-Inflammatory Activity of Quercetin. Lan T, Duan G, Qi Y, et al. Frontiers in Pharmacology. 2024;15:1426944.
  35. Berries (Solanaceae) as Source of Bioactive Compounds for Healthy Purposes: A Review. Teixeira F, Silva AM, Delerue-Matos C, Rodrigues F. International Journal of Molecular Sciences. 2023;24(5):4777.
  36. Polyphenolic Spectrum of Goji Berries and Their Health-Promoting Activity. Jurikova T, Tinakova SM, Ziarovska J, et al. Foods (Basel, Switzerland). 2025;14(8):1387.
  37. Chemical Compositions of Chrysanthemum Teas and Their Anti-Inflammatory and Antioxidant Properties. Li Y, Yang P, Luo Y, et al. Food Chemistry. 2019;286:8-16.
  38. Identification of the Anti-Inflammatory Quality Markers of Chrysanthemi Flos (Juhua) Using Spectrum-Effect Relationships Combined With Bioactivity Re-Evaluation. Liu D, Zhu Q, Zhang L, et al. Biomedical Chromatography : BMC. 2023;37(6):e5630.
  39. Comparative Evaluation of Cultivars of Chrysanthemum Morifolium Flowers by HPLC-DAD-ESI/­MS Analysis and Antiallergic Assay. Xie YY, Qu JL, Wang QL, et al. Journal of Agricultural and Food Chemistry. 2012;60(51):12574-83.
  40. Phytoconstituent Analysis, Bioactivity, and Safety Evaluation of Various Colors of Chrysanthemum Morifolium Flower Extracts for Cosmetic Application. Neatpatiparn A, Junyaprasert VB, Thirapanmethee K, Teeranachaideekul V. Scientific Reports. 2025;15(1):4073.
  41. Evaluation of Anti-Inflammatory and Antioxidant Effectsof Chrysanthemum Stem and Leaf Extract on Zebrafish Inflammatory Bowel Disease Model. Li Y, Liu XJ, Su SL, et al. Molecules (Basel, Switzerland). 2022;27(7):2114.
  42. Mulberry’s Healing Touch: Exploring Ethnobotanical Roots and Medicinal Potentials in the Treatment of Atopic Dermatitis. Ezairjawi MSM, Ünüvar ÖC, Akben C, Taha EM, Ünlü ES. Journal of Ethnopharmacology. 2025;337(Pt 3):118981.
  43. Improved Chemotherapeutic Activity by Morus Alba Fruits Through Immune Response of Toll-Like Receptor 4. Chang BY, Kim SB, Lee MK, Park H, Kim SY. International Journal of Molecular Sciences. 2015;16(10):24139-58.
  44. Toll-Like Receptor 4-Mediated Immunoregulation by the Aqueous Extract of Mori Fructus. Yang XY, Park GS, Lee MH, et al. Phytotherapy Research : PTR. 2009;23(12):1713-20. doi:10.1002/ptr.2818.
  45. Immunoenhancement Effect of Rehmannia Glutinosa Polysaccharide on Lymphocyte Proliferation and Dendritic Cell. Huang Y, Jiang C, Hu Y, et al. Carbohydrate Polymers. 2013;96(2):516-21.
  46. Rehmannia Glutinosa Polysaccharide Promoted Activation of Human Dendritic Cells. Wang Y, Kwak M, Lee PC, Jin JO. International Journal of Biological Macromolecules. 2018;116:232-238.
  47. Rehmannia Glutinosa Polysaccharide Functions as a Mucosal Adjuvant to Induce Dendritic Cell Activation in Mediastinal Lymph Node. Kwak M, Yu K, Lee PC, Jin JO. International Journal of Biological Macromolecules. 2018;120(Pt B):1618-1623.
  48. Rehmannia Glutinosa Polysaccharides Alleviate Cyclophosphamide-Induced Immunosuppression by Enhancing Immunity and Restoring Intestinal Homeostasis. Yu L, Shi X, Lu X, et al. International Journal of Biological Macromolecules. 2025;311(Pt 1):143692.
  49. Anti-Inflammatory Effects of Rehmannia Glutinosa Polysaccharide on LPS-induced Acute Liver Injury in Mice and Related Underlying Mechanisms. Qiao H, Ren H, Liu Q, et al. Journal of Ethnopharmacology. 2025;351:120099.
  50. Topical Application of Rehmannia Glutinosa Extract Inhibits Mite Allergen-Induced Atopic Dermatitis in NC/­Nga Mice. Sung YY, Yoon T, Jang JY, Park SJ, Kim HK. Journal of Ethnopharmacology. 2011;134(1):37-44.
  51. Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Reveal the Mechanism of Radix Rehmanniae in Psoriasis. Mo N, Zhou P, Liu F, et al. Medicine. 2024;103(43):e40211.
  52. The Immunoregulatory Effects of Traditional Chinese Medicine on Psoriasis via Its Action on Interleukin: Advances and Considerations. Wu M, Deng Y, Li S, et al. The American Journal of Chinese Medicine. 2018;46(4):739-750.
  53. Immunoenhancement Effect of Rehmannia Glutinosa Polysaccharide on Lymphocyte Proliferation and Dendritic Cell. Huang Y, Jiang C, Hu Y, et al. Carbohydrate Polymers. 2013;96(2):516-21.
  54. Optimum Conditions for Radix Rehmanniae Polysaccharides by RSM and Its Antioxidant and Immunity Activity in UVB Mice. Sui Z, Li L, Liu B, et al. Carbohydrate Polymers. 2013;92(1):283-8.
  55. Rehmannia Glutinosa Polysaccharides Alleviate Cyclophosphamide-Induced Immunosuppression by Enhancing Immunity and Restoring Intestinal Homeostasis. Yu L, Shi X, Lu X, et al. International Journal of Biological Macromolecules. 2025;311(Pt 1):143692.
  56. Root Extracts Improve Atopic Dermatitis by Regulating Skin Inflammatory and Anti-Oxidative Enzymes in 2,4-Dinitrochlorobenzene (DNCB)-Induced SKH-1 Hairless Mice. Kim TY, Park NJ, Jegal H, et al. Antioxidants (Basel, Switzerland). 2023;12(4):873.
  57. Effects of Radix Adenophorae and Cyclosporine a on an OVA-induced Murine Model of Asthma by Suppressing to T Cells Activity, Eosinophilia, and Bronchial Hyperresponsiveness. Roh SS, Kim SH, Lee YC, Seo YB. Mediators of Inflammation. 2008;2008:781425.
  58. Immunomodulatory Effects of Taiwanese Species on Th1 and Th2 Functionality. Cheng YH, Lin YC, Chen IS, et al. Journal of Immunology Research. 2017;2017:3529859.
  59. Fructus Ligustri Lucidi Suppresses Inflammation and Restores the Microbiome Profile in Murine Colitis Models. Yu W, Sun S, Zhang K, et al. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 2022;106:154438.
  60. Pharmacodynamics, Pharmacokinetics, and Kidney Distribution of Raw and Wine-Steamed Ligustri Lucidi Fructus Extracts in Diabetic Nephropathy Rats. Luan R, Zhao P, Zhang X, et al. Molecules (Basel, Switzerland). 2023;28(2):791. doi:10.3390/molecules28020791.
  61. Anti-Inflammatory Mechanism of Ligustrum Lucidum Ait Based on Network Pharmacology and Molecular Docking. Ji C. Studies in Health Technology and Informatics. 2023;308:372-380.
  62. Bioactivity-Guided Isolation of Immunomodulatory Compounds From the Fruits of Ligustrum Lucidum. Liu J, Liu Z, Wang L, et al. Journal of Ethnopharmacology. 2021;274:114079.
  63. Gardenia Jasminoides Extract Ameliorates DfE-induced Atopic Dermatitis in Mice Through Restoration of Barrier Function and T-Helper 2-Mediated Immune Response. Park SH, Jang S, Kim HK. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2022;145:112344.
  64. Gardenia Jasminoides Extract Without Crocin Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Th2-Related Cytokines in Dfe-Induced NC/­Nga Mice. Park SH, An JE, Jang S, et al. Journal of Ethnopharmacology. 2019;241:112015.
  65. The Gardenia Jasminoides Extract and Its Constituent, Geniposide, Elicit Anti-Allergic Effects on Atopic Dermatitis by Inhibiting Histamine in Vitro and in Vivo. Sung YY, Lee AY, Kim HK. Journal of Ethnopharmacology. 2014;156:33-40.
  66. Properties and Molecular Mechanisms Underlying Geniposide-Mediated Therapeutic Effects in Chronic Inflammatory Diseases. Ran D, Hong W, Yan W, Mengdie W. Journal of Ethnopharmacology. 2021;273:113958.
© 2025 Tangs Clinical TCM. All rights reserved.
Our Logo