Pruritic Urticarial Papules 瘙痒性丘疹荨麻疹
Case Report A 11-year-old boy, with no medical history, was presented with round erythematous pruritic lesions (approximately…
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Allergic Contact Dermatitis 变应性接触性皮炎
Case Report A 30-year-old man was presented with reddish maculopapular rash on his face, neck, chest and back. There was…
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Psoriasis Pathogenesis Review 银屑病发病机理的新进展和回顾
希波克拉底 Hippocrates (460-377BC) 描述了一组斑块、脱皮、鳞屑的皮肤病症状，可能相当于今天的银屑病或麻风病。400年前，哲学家们放弃了亚里士多德的世界观兴高采烈地接受了牛顿世界观来解释生物学并研究医学病理学。在1841年赫伯拉…
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A suspected Mucous Membrane Pemphigoid MMP case 口腔黏膜类天疱疮
A 70-year-old retired female physician was presented with elevated bullae fluid-filled blisters on the roof of her mouth…
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Psoriasiform Spongiotic Dermatitis 银屑病样海绵状皮炎
A 50-year-old male presented with generalised skin lesions for 12 months. He reported brown rashes appearing on the arms…
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What is a possible diagnosis of this case? 可能性的诊断是什么？
A previously healthy 55-year old woman presented with progressive rash that involved her face that had lasted for 5 years…
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Thromboangiitis obliterans (Buerger’s disease) 血栓闭塞性脉管炎(伯格病)
Thromboangiitis obliterans, also known as Buerger’s disease, is an inflammatory disease that result in blood clot…
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Glucocorticoid Induced Adrenal Insufficiency GI-AI 糖皮质激素引起的肾上腺功能不全
On 12 July BMJ published a concerned article about corticosteroids. “Synthetic glucocorticoids are widely used for…
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Retinoid Dermatitis 维A酸皮炎
A 37-year-old otherwise healthy woman presented with a 2 years history of erythema of the face & dry lip sought for…
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A 15-year-old boy with 10-year eczema, 15岁少年10年湿疹
A 15-year-old boy had been treated for 10 years for moderate to severe atopic dermatitis. The neck eczema was his main…
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Stage-3 Pressure Ulcers 褥疮
A 70-year-old female presented with a 1-year history of bedsore. On her right greater trochanter and sacrum, two 3cm-diameter…
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A Sad Story 一个令人悲伤的故事
这是一个令人悲伤的故事。如果你是那个故事里的主角，你能不能突破权威制定的标准化或某种正确思想，或者你敢不敢质疑周围人都觉得理所当然的道理，当大多数人都处在认知误区时，你能拥有跳出来做出改变的勇气吗？每个人对于世界的认知都是片面的，我们都是井底之蛙，区别在于井口的大小。只是我们无法生出改变的勇气，每一个细小的改变都是源于认知的改变，让我们知晓还有更多的可能性。我们愿意选择成为一个会被时间冲淡的故事还是定格时间的传奇？…
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Questions beyond Questions 问题之外的问题
IPhone 12 芯片有125亿颗晶体管，如果损坏，理论上讲无法找出哪一颗出了毛病，所以维修时会把整只芯片换掉。人类细胞核的DNA有30亿碱基对，它们不是人类设计的，不要说哪个错了难以发现，我们对怎样才是正确的都所知甚少。至少计算机科学家知道每一个晶体管是干什么用的，而很多DNA片段是干什么用的，生物学家一无所知。那么什么时候我们会把30亿对怎么用的搞清楚呢？生物学家一定会说，我们以前有一个问题，找到遗传物质基础，解决了一个旧问题后，我们碰到了3万个新问题（3万个基因）。…
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The Wisdom of Bacteria 细菌的智慧
一个成人拥有约30万亿个人体细胞，同时拥有40万亿个细菌，这些细菌占我们体重的1％至3％。尽管细菌经常被视为疾病的一种来源，但细菌大多无害甚至有益。我们的肠道生活着500种大约1公斤（100万亿）微生物。它们是人类非同寻常的伙伴，它们雕刻我们的器官，保护我们免受疾病侵害，分解我们的食物，教育我们的免疫系统，指导我们的行为，用其基因轰击我们的基因组，并赋予我们不可思议的能力。…
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Second degree burn healed in 10 days with herbal formulated HLQ ointment
A 14-year-old student presented with burn injury due to scalding soup exposure 6 hours prior to proper medical attention….
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Postoperative Skin Autograft Wound Care 烧伤植皮术后伤口治疗
Fig. 1 | Postoperative Autograft Burn Wound Treatment. A patient with a severe industrial ethanol burn injury had undergone…
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“I was sick, I want the people to know that I am healed,” he said. 照顾他人的人，必蒙神帮助眷顾。
Patient happily announced that he is fully recovered, and had requested to disclose his full face for the testimonial….
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May Sick Be Healed. 愿受伤的人得医治
A merry heart doeth good like a medicine: but a broken spirit drieth the bones. — KJV Pro 17:22 喜乐的心，乃是良药；…
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What is Acne-like Breakouts? 痤疮样痘痘到底是什么？
Folliculitis is an infammaiton of the superficial or deep hair follicle on hair-bearing skin due to infectious or non-infectious…
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Midnight Feasts Could Cause Melasma 夜宵也会导致黄褐斑
Overnight, keratinocytes (kind of skin epidermis cell) proliferate rapidly, preparing and protecting our outer barrier…
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Epidermis-Honeycomb-Water Cube 表皮-蜂巢-水立方
130 years ago, Lord Kelvin asked how space might be partitioned into cells of fixed equal volume with minimum surface…
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A Topical Steroid Induced Rosacea 外用类固醇诱导出现酒糟性皮炎
Steroid induced Rosacea: persistent facial erythema and inflammatory papulopustules, additional features are facial telangiectasias,…
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Severe Adverse Events Are Associated with Short Courses of Oral Corticosteroids? 皮质激素长期服用有害，短期如何？
Each year, doctors prescribe courses of oral corticosteroids to three quarters of patients with chronic inflammatory disorders…
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Eczema Allergy — A Question of Immune System Imbalance 湿疹、过敏：一个免疫均衡的问题
过敏反应主要和获得性免疫有关。机体对某些抗原物质初次接触以后产生初次免疫应答，此后便有了免疫记忆，当再次接触相同抗原时，就可触发免疫应答或者导致相应的过敏反应。机体从环境当中获取抗原（比如饮食中的一些蛋白质），抗原成分经过抗原递呈细胞，提取抗原信息，刺激调节性T细胞，从而呈递给T辅助细胞，促使T辅助细胞向Th1或者Th2两条途径发展。如果朝着Th2方向发展，就是过敏反应方向。…
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Steroids Rosacea Overlaps Retinoid Dermatitis 激素性皮炎叠加维A酸皮炎
A 54-year-old woman presented with 3 months of facial rash. The rash persisted despite a recent 2-month applicaiton of…
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Why Mortgage Sicken Us? 为什么房贷会让我们生病？
Glucocorticoids [1] plus the sympathetic nervous system [2] enables an organism to survive a physical stressor by activating…
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Avoid Steroids as a First Line Therapy 避免使用类固醇作为一线疗法
A 40-year-old woman presented with a two-month history of worsening rashes on her chest, arms and legs. Twenty months…
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A Systematic Review of Corticosteroid Withdrawal Syndrome 激素戒断综合征
What is Corticosteroid Withdrawal Syndrome CWS?Steroids Withdrawal Syndrome is a distinct clinical adverse effect of steroid….
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If you know the problem, you have already understood half of it. 如果你知道问题所在，那么就已经理解了一半。
《新英格兰医学杂志》2020年7月9日发表了一篇取名为nemolizumab的生物制剂治疗湿疹的三期临床实验如下：…
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Do we have eczema gene(s) – Time to rethink biologics 关于湿疹基因—生物药的再思考
Do we have eczema gene(s) – Time to rethink
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A 64-year-old man with 15-year history of Prurigo Nodularis 64岁罹患结节性痒疹15年
Chronic pruritus (itch) is defined as ‘an unpleasant sensation leading to the desire to scratch lasting at least 6 weeks…
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gene + environment + triggers + chance = phenotype 基因+环境+触发+概率=表型
Know then thyself, presume not God to scan; The proper study of mankind is man. — Alexander Pope, Essay on Man PAST…
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Trade Agreement between Bacteria, Viruses and Human Skin — A fly in the ointment 细菌、病毒与人皮的经贸协定 — 美中不足的共生
Staphylococcus is a group of Gram-positive cocci. It is named because it appears spherical (cocci) and form in grape-like…
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Secret of the Western science：A little piece in a larger jigsaw 科学秘密：一条大锯上的又一个锯齿
Our present system of scientific communication depends almost entirely on the “primary” literature. This has three…
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Third-degree burn in Type 2 Diabetes II型糖尿病3度烧伤
What is diabetes mellitus? All the human cells need sugar to work normally. Sugar enters into the cells with the help…
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Know the medicine before you take it 皮肤用药三思而后行
The prevalence of immue system related skin disorders such as psoriasis, atopic dermatitis (AD) , and allergy has increased…
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Psoriasis in Children 儿童银屑病
Chronic plaque psoriasis is the most common clinical form of psoriasis in children, approximately one-third reported onset…
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WhatsApp Facebook WeChat Testimonial 患者的回馈见证
We thank patients for sending us the photos via WhatsApp/Facebook and giving consent for them to be used as testimonial….
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2nd-degree burns healed in 12 days, no scar left 二度烧伤12天治愈不留疤痕
A second-degree, or partial-thickness, burn penetrates into but not through the dermis. Because the epidermal barrier…
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Prurigo Simplex trigged by hair dyes 染发剂激发的单纯痒疹
Prurigo simplex is symmetrically distributed with small intensely itchy papules, which is in dome-shaped and topped with…
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