What is a possible diagnosis of this case? 可能性的诊断是什么？
A previously healthy 55-year old woman presented with progressive rash that involved her face that had lasted for 5 years…
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Thromboangiitis obliterans (Buerger’s disease) 血栓闭塞性脉管炎(伯格病)
Thromboangiitis obliterans, also known as Buerger’s disease, is an inflammatory disease that result in blood clot…
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Glucocorticoid Induced Adrenal Insufficiency GI-AI 糖皮质激素引起的肾上腺功能不全
On 12 July BMJ published a concerned article about corticosteroids. “Synthetic glucocorticoids are widely used for…
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Retinoid Dermatitis 维A酸皮炎
A 37-year-old otherwise healthy woman presented with a 2 years history of erythema of the face & dry lip sought for…
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A 15-year-old boy with 10-year eczema, 15岁少年10年湿疹
A 15-year-old boy had been treated for 10 years for moderate to severe atopic dermatitis. The neck eczema was his main…
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Stage-3 Pressure Ulcers 褥疮
A 70-year-old female presented with a 1-year history of bedsore. On her right greater trochanter and sacrum, two 3cm-diameter…
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A Sad Story 一个令人悲伤的故事
这是一个令人悲伤的故事。如果你是那个故事里的主角，你能不能突破权威制定的标准化或某种正确思想，或者你敢不敢质疑周围人都觉得理所当然的道理，当大多数人都处在认知误区时，你能拥有跳出来做出改变的勇气吗？每个人对于世界的认知都是片面的，我们都是井底之蛙，区别在于井口的大小。只是我们无法生出改变的勇气，每一个细小的改变都是源于认知的改变，让我们知晓还有更多的可能性。我们愿意选择成为一个会被时间冲淡的故事还是定格时间的传奇？…
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Questions beyond Questions 问题之外的问题
IPhone 12 芯片有125亿颗晶体管，如果损坏，理论上讲无法找出哪一颗出了毛病，所以维修时会把整只芯片换掉。人类细胞核的DNA有30亿碱基对，它们不是人类设计的，不要说哪个错了难以发现，我们对怎样才是正确的都所知甚少。至少计算机科学家知道每一个晶体管是干什么用的，而很多DNA片段是干什么用的，生物学家一无所知。那么什么时候我们会把30亿对怎么用的搞清楚呢？生物学家一定会说，我们以前有一个问题，找到遗传物质基础，解决了一个旧问题后，我们碰到了3万个新问题（3万个基因）。…
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The Wisdom of Bacteria 细菌的智慧
一个成人拥有约30万亿个人体细胞，同时拥有40万亿个细菌，这些细菌占我们体重的1％至3％。尽管细菌经常被视为疾病的一种来源，但细菌大多无害甚至有益。我们的肠道生活着500种大约1公斤（100万亿）微生物。它们是人类非同寻常的伙伴，它们雕刻我们的器官，保护我们免受疾病侵害，分解我们的食物，教育我们的免疫系统，指导我们的行为，用其基因轰击我们的基因组，并赋予我们不可思议的能力。…
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Second degree burn healed in 10 days with herbal formulated HLQ ointment
A 14-year-old student presented with burn injury due to scalding soup exposure 6 hours prior to proper medical attention….
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Postoperative Skin Autograft Wound Care 烧伤植皮术后伤口治疗
Fig. 1 | Postoperative Autograft Burn Wound Treatment. A patient with a severe industrial ethanol burn injury had undergone…
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“I was sick, I want the people to know that I am healed,” he said. 照顾他人的人，必蒙神帮助眷顾。
Patient happily announced that he is fully recovered, and had requested to disclose his full face for the testimonial….
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May Sick Be Healed. 愿受伤的人得医治
A merry heart doeth good like a medicine: but a broken spirit drieth the bones. — KJV Pro 17:22 喜乐的心，乃是良药；…
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What is Acne-like Breakouts? 痤疮样痘痘到底是什么？
Folliculitis is an infammaiton of the superficial or deep hair follicle on hair-bearing skin due to infectious or non-infectious…
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Midnight Feasts Could Cause Melasma 夜宵也会导致黄褐斑
Overnight, keratinocytes (kind of skin epidermis cell) proliferate rapidly, preparing and protecting our outer barrier…
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Epidermis-Honeycomb-Water Cube 表皮-蜂巢-水立方
130 years ago, Lord Kelvin asked how space might be partitioned into cells of fixed equal volume with minimum surface…
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A Topical Steroid Induced Rosacea 外用类固醇诱导出现酒糟性皮炎
Steroid induced Rosacea: persistent facial erythema and inflammatory papulopustules, additional features are facial telangiectasias,…
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Severe Adverse Events Are Associated with Short Courses of Oral Corticosteroids? 皮质激素长期服用有害，短期如何？
Each year, doctors prescribe courses of oral corticosteroids to three quarters of patients with chronic inflammatory disorders…
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Eczema Allergy — A Question of Immune System Imbalance 湿疹、过敏：一个免疫均衡的问题
过敏反应主要和获得性免疫有关。机体对某些抗原物质初次接触以后产生初次免疫应答，此后便有了免疫记忆，当再次接触相同抗原时，就可触发免疫应答或者导致相应的过敏反应。机体从环境当中获取抗原（比如饮食中的一些蛋白质），抗原成分经过抗原递呈细胞，提取抗原信息，刺激调节性T细胞，从而呈递给T辅助细胞，促使T辅助细胞向Th1或者Th2两条途径发展。如果朝着Th2方向发展，就是过敏反应方向。…
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Steroids Rosacea Overlaps Retinoid Dermatitis 激素性皮炎叠加维A酸皮炎
A 54-year-old woman presented with 3 months of facial rash. The rash persisted despite a recent 2-month applicaiton of…
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Why Mortgage Sicken Us? 为什么房贷会让我们生病？
Glucocorticoids [1] plus the sympathetic nervous system [2] enables an organism to survive a physical stressor by activating…
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Avoid Steroids as a First Line Therapy 避免使用类固醇作为一线疗法
A 40-year-old woman presented with a two-month history of worsening rashes on her chest, arms and legs. Twenty months…
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A Systematic Review of Corticosteroid Withdrawal Syndrome 激素戒断综合征
What is Corticosteroid Withdrawal Syndrome CWS?Steroids Withdrawal Syndrome is a distinct clinical adverse effect of steroid….
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If you know the problem, you have already understood half of it. 如果你知道问题所在，那么就已经理解了一半。
《新英格兰医学杂志》2020年7月9日发表了一篇取名为nemolizumab的生物制剂治疗湿疹的三期临床实验如下：…
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Do we have eczema gene(s) – Time to rethink biologics 关于湿疹基因—生物药的再思考
Do we have eczema gene(s) – Time to rethink
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A 64-year-old man with 15-year history of Prurigo Nodularis 64岁罹患结节性痒疹15年
Chronic pruritus (itch) is defined as ‘an unpleasant sensation leading to the desire to scratch lasting at least 6 weeks…
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gene + environment + triggers + chance = phenotype 基因+环境+触发+概率=表型
Know then thyself, presume not God to scan; The proper study of mankind is man. — Alexander Pope, Essay on Man PAST…
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Trade Agreement between Bacteria, Viruses and Human Skin — A fly in the ointment 细菌、病毒与人皮的经贸协定 — 美中不足的共生
Staphylococcus is a group of Gram-positive cocci. It is named because it appears spherical (cocci) and form in grape-like…
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Secret of the Western science：A little piece in a larger jigsaw 科学秘密：一条大锯上的又一个锯齿
Our present system of scientific communication depends almost entirely on the “primary” literature. This has three…
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Third-degree burn in Type 2 Diabetes II型糖尿病3度烧伤
What is diabetes mellitus? All the human cells need sugar to work normally. Sugar enters into the cells with the help…
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Know the medicine before you take it 皮肤用药三思而后行
The prevalence of immue system related skin disorders such as psoriasis, atopic dermatitis (AD) , and allergy has increased…
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Psoriasis in Children 儿童银屑病
Chronic plaque psoriasis is the most common clinical form of psoriasis in children, approximately one-third reported onset…
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WhatsApp Facebook WeChat Testimonial 患者的回馈见证
We thank patients for sending us the photos via WhatsApp/Facebook and giving consent for them to be used as testimonial….
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2nd-degree burns healed in 12 days, no scar left 二度烧伤12天治愈不留疤痕
A second-degree, or partial-thickness, burn penetrates into but not through the dermis. Because the epidermal barrier…
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Prurigo Simplex trigged by hair dyes 染发剂激发的单纯痒疹
Prurigo simplex is symmetrically distributed with small intensely itchy papules, which is in dome-shaped and topped with…
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Cosmetics Induced Dermatitis due to Facial Mask 甘草酸苷美白面膜导致的皮炎
Facial whitening masks/creams/gels are used commonly by Asian women who expects the aesthetic effect on their coloured…
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Severe Eczema in a 20-month-old Child 严重幼儿湿疹
The majority of patients with eczema will present with symptoms in childhood, it may starts at any age, even 2 months…
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Creatine Kinase and Rhabdomyolysis 异维A酸（异维甲酸），肌酸激酶与横纹肌溶解症
Isotretinoin Isotretinoin, retinoic acid (form of victamin A) derivative, is used to treat Pimples (Acne), Psoriasis,…
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Occupational Associcated Hand Eczema 职业性手湿疹
手部湿疹的典型临床症状是红疹、皮肤浸润、细小囊泡、脱皮、糜烂、水肿，角化过度，皲裂(Fig.1A)…
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Biologics (4) IL-4Rα Inhibitors 生物制剂之白细胞介素-4受体α抑制剂
What is Interleukin-4 (IL-4) and Interleukin-4 Receptor (IL-4R) IL-4 is produced by T cells. The T cells are kinds of…
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